Comparative study of cutaneous T-cell lymphoma and adult T-cell leukemia lymphoma

Clinical significance of CD45RO expression on peripheral blood mononuclear cells in HTLV‐I‐infected individuals

“…Our findings on the phenotype of lymphocytes in HTLV-I-infected individuals were similar to those reported by others (Worner et al, 1990;Richardson et al, 1990;Nagatani et al, 1990;Shirono et al, 1989) except for the additional finding that CD28 cells, which are involved in T-cell activation, increased with the progression of ATL. Our findings on the phenotype of lymphocytes in HTLV-I-infected individuals were similar to those reported by others (Worner et al, 1990;Richardson et al, 1990;Nagatani et al, 1990;Shirono et al, 1989) except for the additional finding that CD28 cells, which are involved in T-cell activation, increased with the progression of ATL.…”

“…, CD28 and CD45RO cells in chronic and acute type ATL patients was high, whereas that of CD8 and CD45RA cells was low. Our findings on the phenotype of lymphocytes in HTLV-I-infected individuals were similar to those reported by others (Worner et al, 1990;Richardson et al, 1990;Nagatani et al, 1990;Shirono et al, 1989) except for the additional finding that CD28 cells, which are involved in T-cell activation, increased with the progression of ATL.…”

“…However, there was no significant age difference between patients showing pattern A (52 : 7 years). These results suggested that the carriers and smouldering ATL patients with pattern B were in an immunologically stimulated state (Ila et al, 1991;Chiaffarino et al, 1994;Damle et al, 1993;Lu et al, 1992;Lesslauer et al, 1986;Turka et al, 1990;Van Lier, 1988), or, alternatively, the results could be considered to reflect the presence of ATL cells through cytokines (Richardson et al, 1990;Nagatani et al, 1990;Shirono et al, 1989;Matsuda et al, 1993;Yssel et al, 1989). The CD69 antigen is expressed on T cells in an early activated state via such molecules as CD3 (Axberg et al, 1991;Risso et al, 1991).…”

“…ATL is manifested as a lymphoproliferative disorder, often with a concurrent compromised cellular immune state. Phenotype studies of ATL cells have demonstrated that HTLV-I is tropic for CD4 cells with the predominant cell type harbouring HTLV-I belonging to the CD4 and CD45RO subset (Worner et al, 1990;Richardson et al, 1990;Nagatani et al, 1990;Shirono et al, 1989).…”

Cutaneous T-cell lymphoma in skin of color

“…ATL is a clinically distinct entity from CTCL, in that patients with ATL are more likely to present with generalized lymphadenopathy, hepatosplenomegaly, peripheral blood and bone marrow involvement, and hypercalcemia. 34 However, the phases known as ''smoldering'' and ''chronic'' can present with lesions that clinically and histologically suggest a diagnosis of MF-type CTCL (Fig 18). 35 Testing for HTLV-1 begins with a specific serology test.…”