Comparative study of combined bevacizumab/targeted photocoagulation vs bevacizumab alone for macular oedema in ischaemic branch retinal vein occlusions

Tomomatsu, Yoko; Tomomatsu, Takeshi; Takamura, Yoshihiro; Gozawa, Makoto; Arimura, Shogo; Takihara, Yuji; Inatani, Masaru

doi:10.1111/aos.12721

Cited by 24 publications

(28 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7 Furthermore, our previous study showed that when compared with anti-VEGF therapy alone, targeting retinal photocoagulation to NPAs reduces the severity of macular edema recurrence after anti-VEGF therapy. 8 However, no reports have used an animal RVO model to investigate whether photocoagulation of retinal NPAs suppresses the expression of VEGF. Therefore, the aim of this study was to evaluate whether the laser photocoagulation of NPAs of the retina suppresses ocular VEGF expression in a rabbit RVO model.…”

mentioning

confidence: 99%

Photocoagulation of the Retinal Nonperfusion Area Prevents the Expression of the Vascular Endothelial Growth Factor in an Animal Model

Gozawa

Takamura

Miyake

et al. 2017

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

PURPOSE. The purpose of this study was to evaluate whether photocoagulation of the retinal nonperfusion area suppresses ocular vascular endothelial growth factor (VEGF) expression in a rabbit retinal vein occlusion (RVO) model. METHODS.The retinas of pigmented rabbits were made ischemic by a laser on the main branch of retinal veins following intravenous injection of Rose Bengal. The eyes were enucleated before treatment and at 1, 7, and 14 days after laser occlusion. VEGF protein levels in the vitreous humor, sensory retina, and retinal pigment epithelium-choroid were measured with enzyme-linked immunosorbent assay. In situ hybridization of VEGF messenger RNA was performed to detect the location of VEGF expression in the sensory retina.RESULTS. In the vitreous body, the VEGF protein level in the RVO group, but not that in the RVO þ panretinal photocoagulation group, significantly increased on day 14. In the retina, the VEGF protein level in the RVO þ panretinal photocoagulation group was significantly higher than that in the RVO group on day 1, but was significantly lower than that in the RVO group on days 7 and 14. In the in situ hybridization analysis, the RVO group showed a high expression of VEGF in the inner nuclear and ganglion cell layers on days 7 and 14. In contrast, VEGF expression in the RVO þ panretinal photocoagulation group was strongly suppressed in both the inner nuclear and ganglion cell layers on days 7 and 14.CONCLUSIONS. This study is the first using an animal RVO model to demonstrate that laser photocoagulation of the retinal nonperfusion area suppresses VEGF-A expression in the retina.

show abstract

mentioning

confidence: 99%

Photocoagulation of the Retinal Nonperfusion Area Prevents the Expression of the Vascular Endothelial Growth Factor in an Animal Model

Gozawa

Takamura

Miyake

et al. 2017

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Interestingly, they also observed that untreated NP anterior to the globe equator was significantly associated with ME. Tomomatsu et al 16 and Singer et al 17 reported that TRP to these NP areas following intravitreal bevacizumab injection reduced the severity of recurrent ME compared with intravitreal bevacizumab injection alone.…”

Section: Discussionmentioning

confidence: 99%

Ultra-Wide-Field Fluorescein Angiography–Guided Normalization of Ischemic Index Calculation in Eyes With Retinal Vein Occlusion

Wang

Falavarjani

Nittala

et al. 2018

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE. The purpose of this study was to compare the use of central and montaged ultrawide-field fluorescein angiography (UWFFA) images for calculating the area of nonperfusion (NP) and ischemic index (ISI) in patients with retinal vein occlusion (RVO) and macular edema (ME) and to correlate these measurements with best-corrected visual acuity (BCVA) and central macular thickness (CMT).METHODS. Thirty eyes of 30 RVO patients with recurrent ME were enrolled. Baseline UWFA images were sent to the Doheny Image Reading Center for quantitative analysis by certified graders. The association between ISI from the various zones and BCVA and CMT was examined by Spearman rank correlation and compared. Generalized linear models (GLMs) were used to analyze associations between BCVA and disease status.RESULTS. The NP area and ISI for central and montaged images were not significantly different for any retinal zone. A modest but statistically significant negative linear correlation was observed between BCVA and ISI, ranging from r ¼ À0.3825 in the perimacular area (PMA) to r ¼ À0.584 in the far peripheral area (FPA). On GLM analysis, both PMA (b ¼ À1.059; 95% confidence interval: À1.74 to À0.378) and FPA (b ¼ À0.505; 95% confidence interval: À0.988 to À0.021) were significant independent predictors of BCVA. We found no correlation between ISI from the various zones and CMT in this cohort. CONCLUSIONS.Montaging of UWFFA images may not be required to adequately quantify and represent areas of NP in eyes with RVO. NP in both the PMA and peripheral retina appear relevant to visual function, highlighting the importance of evaluating the retinal periphery in these individuals.

show abstract

“…Tomomatsu et al [22] reported that laser photocoagulation for peripheral NPAs prevented the recurrence of ME in BRVO. However, Campochiaro et al [23] reported that scatter photocoagulation did not reduce macular edema in BRVO.…”

Section: Discussionmentioning

confidence: 99%

Structural and Functional Analyses of Retinal Ischemia in Eyes with Retinal Vein Occlusion: Relationship with Macular Edema or Microaneurysm Formation

et al. 2018

View full text Add to dashboard Cite

Purpose: To study the structural and functional changes of retinal ischemia and investigate their association with macular edema (ME) or microaneurysm (MA) formation in eyes with retinal vein occlusion (RVO). Methods: Sixty eyes of 30 patients (27 eyes with branch [b]RVO, 3 with central RVO, and 30 fellow eyes) were retrospectively reviewed. Optical coherence tomography (OCT), OCT angiography (OCTA), and microperimetry were performed simultaneously to measure retinal thickness and sensitivity. The presence of ME or MA was also assessed using OCT and fluorescein angiography. Results: The mean retinal sensitivity in the nonperfused areas (NPAs) deteriorated, and this was significantly (r = –0.379, p = 0.0391*) and inversely correlated with duration from disease onset. ME and MA were unlikely to be observed around the area where the retinal sensitivity decreased. In the NPAs, the mean retinal thickness of the superficial capillary plexus (SCP) (p < 0.0001), deep capillary plexus (DCP) (p = 0.0323), and outer retina (p = 0.0008) were significantly thinner than those in the fellow eyes, respectively. Multivariate regression analysis revealed that the thicknesses of the DCP (β: 0.3107, p = 0.0007) and outer retina (β: 0.3482, p = 0.0001) were the independent correlative factors of the retinal sensitivity, but that SCP thickness was not. Conclusion: Deep retinal thinning in NPAs was correlated significantly with a decreased retinal sensitivity, which might be a negative predictor of ME and MA in eyes with RVO.

show abstract

Comparative study of combined bevacizumab/targeted photocoagulation vs bevacizumab alone for macular oedema in ischaemic branch retinal vein occlusions

Cited by 24 publications

References 30 publications

Photocoagulation of the Retinal Nonperfusion Area Prevents the Expression of the Vascular Endothelial Growth Factor in an Animal Model

Photocoagulation of the Retinal Nonperfusion Area Prevents the Expression of the Vascular Endothelial Growth Factor in an Animal Model

Ultra-Wide-Field Fluorescein Angiography–Guided Normalization of Ischemic Index Calculation in Eyes With Retinal Vein Occlusion

Structural and Functional Analyses of Retinal Ischemia in Eyes with Retinal Vein Occlusion: Relationship with Macular Edema or Microaneurysm Formation

Contact Info

Product

Resources

About