Comparative study of clinical profile between familial and sporadic Parkinson's disease

Jukkarwala, Anis

doi:10.5455/jmas.263847

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Parkinson's Disease1

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2021

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“…Among familial PD patients, important mutations in DJ-1 and GBA are implicated in maintaining normal mitochondrial function [94,95]. Although the biogenesis of these two categories is different, a significant difference between both groups for clinical profile or motor symptoms cannot be observed [113]. Since the pathogenic cause of PD is complicated and is still unknown, an effective strategy that can radically cure PD remains unavailable [114].…”

Section: Parkinson's Diseasementioning

confidence: 99%

Mitophagy Regulates Neurodegenerative Diseases

Cen

Zhang

Zhou

et al. 2021

Cells

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Mitochondria play an essential role in supplying energy for the health and survival of neurons. Mitophagy is a metabolic process that removes dysfunctional or redundant mitochondria. This process preserves mitochondrial health. However, defective mitophagy triggers the accumulation of damaged mitochondria, causing major neurodegenerative disorders. This review introduces molecular mechanisms and signaling pathways behind mitophagy regulation. Furthermore, we focus on the recent advances in understanding the potential role of mitophagy in the pathogenesis of major neurodegenerative diseases (Parkinson’s, Alzheimer’s, Huntington’s, etc.) and aging. The findings will help identify the potential interventions of mitophagy regulation and treatment strategies of neurodegenerative diseases.

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