Comparative Study of Clearance of 10% and 20% Fat Emulsion

Kaminski, Mitchell V.; Abrahamian, V.; Chrysomilides, Sonia A.; Nasr, Norma J.; Armstrong, Michael K.; Lynch, Don M.

doi:10.1177/0148607183007002126

Cited by 10 publications

(3 citation statements)

References 13 publications

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“…The clearance k is statistically similar regardless of the fat emulsion injected, but the Lipovenos k tended to be slower when compared with the Intralipid's one. These k values were comparable to those reported for Intralipid in healthy and in critically ill patients 11,13 as well as in the large variations around the mean within groups. As previously published by Ros~n e r ;~ the highest measured fat particle levels were observed 5 min after the bolus in all patients regardless of the fat emulsions injected.…”

Section: Triglycerides and Free Fatty Acidssupporting

confidence: 88%

Comparative clearance of two new fat emulsions‐‐Hausmann Lipid 20% and Lipovenos 20%‐‐versus intralipid 20%

Pichard

Johner²,

Pilet³

et al. 1990

J Parenter Enteral Nutr

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Intravenous fat tolerance tests (IVFTT) were performed in 13 healthy men volunteers once a day during three consecutive days in order to compare three different fat emulsions randomly administered (Intralipid 20%, Hausmann Lipid 20%, Lipovenös 20%). The amount of fat was 0.1 g/kg of body weight injected within 32 +/- 4 sec and the lipid clearance was determined over 40 min. The fractional removal rates k for the three different emulsions of fat were 5.38 +/- 1.67, 4.95 +/- 2.15, 3.92 +/- 1.31 %/min, respectively (mean +/- SD), and the half-life time of clearance T1/2 were 14.5 +/- 5.8, 16.9 +/- 7.4, 19.2 +/- 5.2 min, respectively. The highest fat particles values were observed 5 min after the bolus and all concentrations remained within the normal range (0-3 g/liter) during the study. In addition, no adverse effects were observed throughout the IVFTT. The nonparametric analysis of variance (Friedman's test) showed no significant differences between groups, even if Lipovenös 20% tended to be cleared more slowly than Intralipid 20%. These results suggest that the three fat emulsions are similarly eliminated from the blood stream and do not result in acute intolerance. Further studies based on prolonged infusion should be carried out to determine whether the two new emulsions might be alternatively used for intravenous nutritional support.

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Section: Triglycerides and Free Fatty Acidssupporting

confidence: 88%

Comparative clearance of two new fat emulsions‐‐Hausmann Lipid 20% and Lipovenos 20%‐‐versus intralipid 20%

Pichard

Johner²,

Pilet³

et al. 1990

J Parenter Enteral Nutr

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“…Triglyceridemia is transient whereas cholesterolemia and phospholipidemia are much more persistent (1,7,8). The latter can be prevented by infusion of a 20% lipid emulsion rather than the commonly used 10% emulsion (2)(3)(4). The two lipid emulsions differ in the ratio of phospholipid to triglyceride; both contain the same type (lecithin) and amount of phospholipid (1.2 g/dl), the difference being the amount of triglyceride, which is 200mg/ml in the 20% and lOOmg/ml in the 10% emulsion.…”

Section: Discussionmentioning

confidence: 99%

“…Clearing of lipid emulsions in preterm infants maintained on total parenteral nutrition (TPN) depends on the amount infused, the rate of infusion and the presence of heparin in the iv solution (1). The concentration of the infused lipid (1 0 % versus 20% Intralipid) is known to affect clearing efficiency, the better clearing of 20% Intralipid being attributed to the lower phospholipid/triglyceride ratio (2)(3)(4). The relationship between lipid clearance (10% versus 20% Intralipid) and activity of lipolytic enzymes has, however, not been investigated.…”

mentioning

confidence: 99%

Plasma lecithin: cholesterol acyltransferase and plasma lipolytic activity in preterm infants given total parenteral nutrition with 10% or 20% Intralipid

Goel¹,

Hamosh

Stahl

et al. 1995

Acta Paediatrica

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The effect of 10% or 20% Intralipid on lipid clearing enzymes, plasma lipids and apoproteins was investigated during the first 5 days after birth in 37 premature infants maintained on total parenteral nutrition; 21 infants received 20% and 16 received 10% Intralipid, respectively. Lipid was infused over a 20-h period at rates of 1, 2 and 3 g/kg/day on consecutive days. Plasma lecithin: cholesterol acyltransferase (LCAT) activity was low and increased significantly (p<0.05) only during infusions of 3 g/kg/day in both groups of infants. Plasma lipolytic activity was generally not affected by the regimen or preparation (10% or 20%) of Intralipid infused, except for higher (p<0.05) levels at 3 g/kg/day of 20% compared with prelipid infusion. Plasma triglyceride concentrations wer similar after 10% or 20% Intralipid, whereas plasma total cholesterol was significantly higher during infusion of 2 and 3 g/kg/day of 10% compared with 20% Intralipid. The efficient clearing of 20% Intralipid might be related to the lower lecithin: triglyceride ration which is compatible with the low LCAT activity of premature infants.

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Enteral and Parenteral Nutrition in the Elderly Patient

Dworkin

1988

Contemporary Geriatric Medicine

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Comparative Study of Clearance of 10% and 20% Fat Emulsion

Cited by 10 publications

References 13 publications

Comparative clearance of two new fat emulsions‐‐Hausmann Lipid 20% and Lipovenos 20%‐‐versus intralipid 20%

Comparative clearance of two new fat emulsions‐‐Hausmann Lipid 20% and Lipovenos 20%‐‐versus intralipid 20%

Plasma lecithin: cholesterol acyltransferase and plasma lipolytic activity in preterm infants given total parenteral nutrition with 10% or 20% Intralipid

Enteral and Parenteral Nutrition in the Elderly Patient

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