Comparative Study of Chronotropic and Inotropic Effects of Dopamine and Seven Derivatives on the Isolated, Blood‐perfused Dog Atrium

Chiba, Shigetoshi

doi:10.1111/j.1440-1681.1978.tb00648.x

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…Moreover, an intra-arterial injection of dobutamine to the isolated atrium caused more potent chrono tropic and inotropic effects than that of dopamine, with essentially the same pattern of response as that to isoproterenol. In isolated atrial preparations, the ratio of the inotropic effect to the chronotropic effect for each dose of the drugs was studied in our previous reports (7)(8)(9)(10). Figure 7 shows the ratio for dobutamine determined in the present study as well as the ratios for other drugs determined in both present and previous studies.…”

Section: Discussionmentioning

confidence: 92%

“…Figure 7 shows the ratio for dobutamine determined in the present study as well as the ratios for other drugs determined in both present and previous studies. Glucagon showed an ob viously selective chronotropic action (7) and N-glycylglycylleucyl-dopamine a rela tively selective inotropic action (10). How ever, dobutamine shows a ratio similar to dopamine, no repinephrine, epinephrine or dibutyryl cyclic AMP, indicating that these compounds have no selective inotropic action on the isolated heart preparation.…”

Section: Discussionmentioning

confidence: 99%

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Cardiovascular effects of dobutamine, dopamine and isoproterenol on the whole animal and isolated cross-perfused atrium in dogs.

et al. 1983

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Abstract-The right atrium of the dog was isolated and cross-perfused with arterial blood of another (donor) dog anesthetized with pentobarbital. When dobutamine, dopamine or isoproterenol was administered intravenously to the donor dog, the following changes were elicited in them: Dobutamine caused slight biphasic changes in heart rate. Dopamine induced biphasic changes in blood pressure and heart rate. Isoproterenol produced a decrease in blood pressure and a marked increase in heart rate. All these 3 catecholamines, however, induced positive chronotropic and inotropic effects in a similar fashion on the isolated atrium cross-perfused with blood of the donor dog. When injected into the cannulated sinus node artery of the isolated dog atrium, dobutamine, dopamine or isoproterenol induced monophasic positive chronotropic and inotropic effects in a dose-related manner, although the potency of each of the drugs was different. Dobutamine-induced effects were abolished by propranolol, but not modified by imi pramine which suppressed significantly tyramine-and dopamine-induced effects. The difference in dobutamine-induced chronotropic effect between the whole animal and the isolated atrium may be due mainly to modification by extracardiac factors in the whole animal.Dobutamine is a synthetic catecholamine developed by Tuttle and Mills (1) to provide a clinically more useful inotropic agent having less side effects. Indeed, dobutamine directly increases myocardial contractility without inducing marked tachycardia or greatly changing peripheral arterial resistance in intact dogs (1-3). In the cat papillary muscle, dobutamine increases the con tractility more but the automaticity less than did isoproterenol (1). However, no report is available concerning the effect of dobutamine assessed in isolated dog heart preparations. Thus, in the present study, we attempted to compare chronotropic and inotropic effects of dobutamine, dopamine and isoproterenol using the isolated dog atrial preparation which was perfused with the arterial blood of the donor dog (4, 5). We administered these three catecholamines intravenously to the donor dog or intraarterially to the isolated atrium to observe their direct cardiac chrono tropic and inotropic effects and probable modification of these effects by extracardiac factors. Materials and MethodsTwenty mongrel dogs weighing 11-25 kg were anesthetized with sodium pentobarbital (30 mg/kg, i.v.). The right atrium was quickly removed and immersed in Tyrode solution at 4-10°C. The right atrium was then perfused with blood from the carotid artery of a heparinized donor dog. Perfusion pressure was kept constant at 100 mm Hg. The atrium which was usually subjected to a resting tension of 2 g was suspended in the bath filled with blood maintained at a constant temperature of 37'C. Atrial rate and isometric tension development of the isolated atrium and systemic blood pressure and heart rate of the donor dog were simultaneously measured during the experiments. The details of the preparation are descri...

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Cardiovascular effects of dobutamine, dopamine and isoproterenol on the whole animal and isolated cross-perfused atrium in dogs.

et al. 1983

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“…Recently, several dopamine derivatives were synthesized and were found to protect the molecule at its metabolically vulnerable sites (8)(9)(10)(11)(12). In the present study, secretory re sponses to dopamine and seven amino acid conjugated derivatives of dopamine were com pared, using the blood-perfused dog pancreas preparation.…”

mentioning

confidence: 99%

Local Anesthetic Activity of β-Adrenergic Blocking Drugs in the Crayfish Giant Axon, with Reference to Calcium Ion

Iwatsuki

Chiba

1980

Japanese Journal of Pharmacology

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Abstract-The secretory responses to seven dopamine amino acid conjugated derivatives were compared with those to dopamine, using blood-perfused canine pancreas pre parations. Each of these dopamine derivatives produced a dose dependent increase in the secretion of pancreatic juice. The rank order of the secretory responses and relative potency (dopamine =1) was: N-Ileu-dopamine (0.4)>N-Ala-Glu-dopamineThe duration of action of doses of the derivatives which produced approximately equal secretory responses was about 1.22.7 times longer than that of dopamine. Dopamine and N-Ileu-dopamine which has the most potent secretagogue property among seven dopamine derivatives produced a secretin-like secretion of the pancreatic juice con taining a high concentration of bicarbonate but had little effect on protein output with lower amylase activity.Dopamine is a precursor of noradrenaline and has characteristics which form other catecholamines, on systemic blood pressure (1, 2), in the renal or mesenteric vascular bed (1, 3) and in the coronary circulation (4). These effects of dopamine may be the result of actions on specific dopamine receptors (5).It has been reported that dopamine produced an increase in the secretion of pancreatic juice in dogs but that noradrenaline had no effect on pancreatic secretion (6). As the secretagogue effect of dopamine was antagonized by haloperidol it was suggested that there were specific dopamine receptors in the dog pancreas (7).Recently, several dopamine derivatives were synthesized and were found to protect the molecule at its metabolically vulnerable sites (8-12). In the present study, secretory re sponses to dopamine and seven amino acid conjugated derivatives of dopamine were com pared, using the blood-perfused dog pancreas preparation.Moreover, we attempted to determine among the seven dopamine derivatives, compositions of the pancreatic juice induced by secretin, dopamine and N-lieu-dopamine which had the most potent secre tagogue properties. MATERIALS AND METHODSTen mongrel dogs of either sex, weighing from 44 to 17 kg, were fasted for 24 hr and anaesthetized with sodium pentobarbital (30 mg/kg, i.v.). During the experimental pro

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Cardiovascular Effects of Dobutamine, Dopamine and Isoproterenol on the Whole Animal and Isolated Cross-Perfused Atrium in Dogs

Chiba

Watanabe

Kobayashi

et al. 1983

Japanese Journal of Pharmacology

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Comparative Study of Chronotropic and Inotropic Effects of Dopamine and Seven Derivatives on the Isolated, Blood‐perfused Dog Atrium

Cited by 6 publications

References 11 publications

Cardiovascular effects of dobutamine, dopamine and isoproterenol on the whole animal and isolated cross-perfused atrium in dogs.

Cardiovascular effects of dobutamine, dopamine and isoproterenol on the whole animal and isolated cross-perfused atrium in dogs.

Local Anesthetic Activity of β-Adrenergic Blocking Drugs in the Crayfish Giant Axon, with Reference to Calcium Ion

Cardiovascular Effects of Dobutamine, Dopamine and Isoproterenol on the Whole Animal and Isolated Cross-Perfused Atrium in Dogs

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