Comparative study of calcipotriol (MC 903) ointment and betamethasone 17-valerate ointment in patients with psoriasis vulgaris

Comparative Efficacy of Topical Calcipotriol (0.005%) Versus Topical Corticosteroid (Betamethasone 0.1%) in Treating Plaque Type Psoriasis

“…These findings were consistent with other studies. [15][16][17] Molin et al conducted a study and showed that the mean reduction in the PASI in patients treated with calcipotriol was 3.3 and in patients treated with betamethasone 2.8. The reduction in PASI was statistically significant in both treatment groups.…”

“…Calcipotriol ointment was as effective as betamethasone 17-valerate ointment as measured by the PASI and superior as measured by selfassessment in patients with stable plaque psoriasis. 16 Kragballe et al carried out a study to observe the therapeutic efficacy of topical calcipotriol and betamethasone in psoriasis in a multicentre randomized, double blind right/left trial. Three hundred forty five patients with psoriasis vulgaris of symmetrical distribution were treated twice daily for 6 weeks with calcipotriol ointment and betamethasone ointment randomly assigned to opposite side of the body.…”

Progress in self treatment for psoriasis vulgaris

“…Irritant reactions have been reported in up to 19.5% of patients using calcipotriol in short-term studies (33). These are not usually severe but occasionally require treatment to be discontinued.…”

“…Hypercalcaemia has developed during calcipotriol treatment, though only when very large quantities were applied to a large surface area (33,57). Serum calcium was monitored during all the studies performed on this compound and none has shown a rise in the mean level or hypercalcaemia in any subject using up to 1OOg of ointment (50pg/g) weekly.…”

“…In large, multicentre, double-blind studies of right/ left (32), and parallel group design (33), calcipotriol ointment (50 pg/g) has been compared to betamethasone valerate ointment (0.1%). Each treatment was applied twice daily for 6 weeks.…”