Comparative Study of Attenuation of Hemodynamic Changes during Laryngoscopy and Intubation Using Intravenous lidocaine and Intravenous Dexmedetomidine in Patients Undergoing Abdominal Surgery

Abstract

Background: Ligocaineis an aminoethylamide, a prototype of amide local anaesthetic group and its IV uses blunted pressure response to intubation. 1.5 mg/kg lignocaine 3 min prior to intubation has shown good result. Dexmedetomide, an α adrenergic agonist has anaesthetic sparing, analgesic, sedative, anxiolytic, sympathetic effect and it decreases central nervous system sympathetic outflow in a dose dependent side effect. Aims and Objectives: To compare the efficacy of intravenous dexmedetomidine with intravenous lidocaine in attenuating the cardiovascular response to laryngoscopy and intubation. Material and Methods: After approval taken by ethical committee, 90 consents patients age group 18-65 years were taken as a study group. Results: Heart rate in Group Control Group increased significantly when compared to Group Lidocaine Group during intubation, after 1 minute, after 3 minutes after 5 minutes, and after 10 minutes of intubation. Similarly Heart rate in Group Control Group increased significantly when compared to Group D Dexmedetomidine Group during intubation, after 1 minute, after 3 minutes, after 5 minutes, and after 10 minutes of intubation. The decrease in heart rate appeared more in Group Dexmedetomidine Group at all intervals when compared to Group Lidocaine Group. Conclusion: Dexmedetomidine 1mcg/kg 10 min prior >lidocaine 1.5 mg/kg 90 sec prior >control group.