Comparative Study of Antioxidant Activity of Some Amides

Abstract

The aim of this study was to evaluate the antioxidant activities of five amides: benzanilide 1, dodecanilide 2, N-cyclohexyloctamide 3, acetanilide 4, and acetaminophen (paracetamol) 5, and to compare them to those of standard antioxidants, i.e. butylated hydroxyanisole (BHA), butylated hydroxy toluene (BHT), ascorbic acid (vitamin C) and α-tocopherol (vitamin E). Three common experimental tests were used to assess their antioxidant properties: 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, ferric ions reducing antioxidant power (FRAP) and β-carotene/linoleic acid assays. The amides 1-3 proved to be antioxidant as per three methods; the fatty anilide 2 showed the highest radical scavenging activity, whereas the fatty amide 3 showed the lowest one. Increasing the concentration resulted in an increased ferric reducing antioxidant power for all the examined amides; the reducing power of fatty anilide 2 was relatively higher than those of benzanilide 1 and fatty amide 3. Oxidation of the linoleic acid was strongly inhibited by all amides. The obtained results were comparable to antioxidant properties of the standard antioxidants.

Larvicidal effect of hydroethanolic extract from the leaves of Acmella oleracea L. R. K. Jansen in Aedes aegypti and Culex quinquefasciatus

“…The mixture was stirred at 450 rpm for 30 min and kept in an environment without light at room temperature. The analysis was performed using a spectrophotometer (UV-VIS Shimadzu) with each sample containing 1.0 mL of the extract at the concentration to be tested and 1.0 mL of ethanol (Borges and Castle, 2015;Malki et al, 2017). The experiment was carried out in triplicate.…”

Oxidative responses and defense mechanism of hyperpigmented P. aeruginosa as characterized by proteomics and metabolomics

“…3) ). N -phenylacetamide is also known as acetanilide or acetanil (Malki et al, 2017[ 26 ]). Acetanilide is used as anti-oxidant molecules and is also used as a precursor in the synthesis of penicillin and other pharmaceuticals compounds (Prema and Sivakumar, 2015[ 38 ]).…”

Substituted quinolinones. 31. Some new pyrano[3,2‐c]quinoline‐3‐carboxamides and their antioxidant activity

“…On the other hand, carboxamide derivatives exhibited a vital importance in medicinal applications. Thus, literature is full of examples for bioactive carboxamides especially as antioxidant agents . Many palmitic acid amides were described as potent anti‐inflammatory and antioxidant agents .…”