Comparative Study of Anti - Inflammatory Activity of Newer Macrolides With Etoricoxib

J, Gajendra Naidu; Madhavi, E.; Konda, Venu Gopala Rao; Y, Venkata Ramana; Rajeshwaramma, G

doi:10.14260/jemds/2014/2153

jemds

2014

DOI: 10.14260/jemds/2014/2153

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Comparative Study of Anti - Inflammatory Activity of Newer Macrolides With Etoricoxib

Gajendra Naidu J¹,

E. Madhavi²,

Venu Gopala Rao Konda³

et al.

Abstract: The present study was designed to investigate the anti-inflammatory activity of macrolides and to compare with standard non-steroidal anti-inflammatory drug (NSAID) etoricoxib. This study was conducted in male wistar albino rats by inducing edema with 1% carrageenan. Animals were divided into 5 groups with 6 in each and paw edema volume was measured by digital plethysmograph before and 3hrs after 1% carrageenan administration. Percentage of inhibition of paw edema was calculated. Results showed macrolides havi… Show more

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2019

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Evaluation of Phytochemical and Pharmacological Activity of Carissa carandas L. Fruits at Three Different Stages of Maturation

Saher¹,

Narnawre²,

Patil³

2019

Drug Res (Stuttg)

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Inflammation plays an important role in various diseases with high prevalence within populations such as rheumatoid arthritis, ulcer, atherosclerosis and asthma. Many drugs are available in the market for inflammatory diseases but they exhibit several unwanted side effects. Therefore, alternative treatments with safer compounds are needed. The plant Carissa carandas L. plant is used traditionally for the treatment of various diseases. Hence to validate its traditional use, the present study has envisaged screening different solvents extract of Carissa carandas fruit for their phytochemical and pharmacological activity especially the anti-inflammatory activity of the fruits at 3 different stages of maturation. The n-hexane and chloroform extracts of immature, mature and ripe fruits showed positive tests for steroids and triterpenoids, whereas acetone extract showed positive tests for steroids, triterpenoids, alkaloids, tannins, sugar, saponins except for triterpenoids in immature fruits. The hydroalcoholic extract showed presence of alkaloids, tannins, sugars, saponin and flavonoids. The highest concentration of phenol, flavonoids and ascorbic acid were found to be more in acetone extract of mature fruits and of carbohydrates in ripe fruits. The hydroalcoholic extract also exhibited similar pattern. The anti-inflammatory property was evaluated by using different models like carrageenan induced paw edema in Wistar rats and cotton pellets induced granuloma. There was a consistent increase in % inhibition of inflammation at concentrations of 100 and 200 mg/kg up to 3 h. The highest activity was at 3 h with 200 mg/kg dose. Thus the present work has clearly proved that the acetone extract of mature fruits have considerable anti-inflammatory activity.

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Evaluation of Phytochemical and Pharmacological Activity of Carissa carandas L. Fruits at Three Different Stages of Maturation

Saher¹,

Narnawre²,

Patil³

2019

Drug Res (Stuttg)

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show abstract

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Comparative Study of Anti - Inflammatory Activity of Newer Macrolides With Etoricoxib

Cited by 1 publication

References 18 publications

Evaluation of Phytochemical and Pharmacological Activity of Carissa carandas L. Fruits at Three Different Stages of Maturation

Evaluation of Phytochemical and Pharmacological Activity of Carissa carandas L. Fruits at Three Different Stages of Maturation

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