Comparative study of a direct and a new indirect gas-liquid chromatographic procedure for the estimation of water in natural products

An Efficient and Reliable Gas Chromatographic Method for Measuring Liquid-Liquid Mutual Solubilities in Alkylbenzene + Water Mixtures: Toluene + Water from 303 to 373 K

“…Some of their recommendations have been used in the routine analysis of trace organics in water (4). There are also many suggestions for the GC analysis of trace water in an organic solvent (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). However, none of these has been widely accepted in practice, presumably for the following reasons: (1) the Karl Fischer titration method has become a de facto standard method for water content determination, and highly specialized and automated commercial units are readily available, (2) the reliability and accuracy of GC methods have not been well demonstrated for routine applications, (3) some GC methods are complicated and require both specialized personnel and analytical equipment which may not be readily available, and (4) some GC methods are tedious and inefficient and do not have general applicability.…”