Comparative Study of 2 Doses of Sufentanyl (2.5 Μg versus 5 Μg) in the Rachianesthsia for Cesarean Section

Abstract

In contrast, significant side effects such as arterial hypotension and respiratory depression Abstract Background: During the Rachianesthesia, many substances including opioids, are administered intrathecally as adjuvants of local anesthetics. The aims, was to compare the efficacy of spinal anesthesia with bupivacaine 10 mg plus sufentanyl 2,5 versus 5 micrograms during caesarean section. Methods: This is a descriptive, comparative and retrospective study conducted in the operating room of the obstetrics and gynecology department of the University Hospital of Treichville from April 2017 to March 2018. Were included in the study, 80 patients classified ASA I and II who underwent spinal anesthesia for cesarean section either with the combination of bupivacaine 10 mg + sufentanyl 2.5 g (Group I, n = 37) or Bupivacaine 10 mg + sufentanyl 5 μg (Group II, n = 43). Our primary evaluation criteria were: duration of sensory and motor block, ephedrine consumption, and incidence of side effects peropeatively. Comparisons were made using the Chi 2 test, with a threshold of p ≤ 0.05 considered significant. Results: The criteria evaluated in our patients studied were comparable: age (p = 0.315), size (p = 0.43), duration of motor block (p = 0.616), duration of postoperative analgesia (p = 0.30), as well as pruritus (p = 0.69). The incidence of side effects such as: Hypotension (p = 0.00), somnolence (p = 0.000), nausea (p = 0.00) vomiting (p = 0.04), were higher in Group II than in Group I. The distribution of patients according to the consumption of ephedrine was: 0.32 ±1.97 (Gr I) vs 16.14 ± 7.29 (Gr II), with a significant stastiscal difference (p=0.000) Conclusions: Spinal anesthesia with bupivacaine 10 mg and sufentanyl 2.5 mcg provides satisfactory operating conditions and reduction of side effects compared to sufentanyl 5μg.