Comparative study in infertile couples with and without Chlamydia trachomatis genital infection

Zhu, Yuanchang; Yin, Bo; Wu, Tong; Ye, Lijun; Chen, Chunmei; Zeng, Yong; Zhang, Yaou

doi:10.1186/s12978-016-0271-4

Cited by 10 publications

(7 citation statements)

References 21 publications

(20 reference statements)

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“…Zhu and colleagues reported a significant correlation between chronic chlamydial infection and infertility in males and females. In a fiveyear investigation (2010 to 2014), they found an increasing prevalence of C. trachomatis infection (by about 3.15%) and reported no significant effect of the infection on semen parameters (P > 0.05) (33).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Chlamydia trachomatis and Listeria monocytogenes in Infertile Men and the Effect on Semen Parameters

Tohidpour

Shahhosseiny

Mehrabian

et al. 2020

Jundishapur J Microbiol

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Background: Infertility is one of the serious problems in gynecology and one of the most important issues of concern in couples. Meanwhile, a significant rise in infertility is recently reported in Iran due to the infections and harsh environmental conditions. Objectives: The current study aimed to detect Chlamydia trachomatis and Listeria monocytogenes in males with infertility using PCR, and to evaluate bacteriospermia effects of the studied bacteria on semen parameters. Methods: Semen specimens of 100 infertile men were collected. Then, each specimen was divided into two parts: the first part was tested by semen analysis according to the WHO guidelines and the second was tested using the PCR method. The PCR intended to identify C. trachomatis and L. monocytogenes. Results: Out of 100 semen samples, 20% were positive for C. trachomatis, 3% were positive for L. monocytogenes, and 3% were positive for both bacteria (coinfection). The leukocyte count was higher than the normal range (0 - 1 Mil/mL) in all semen specimens. The prevalence of C. trachomatis in azoospermic patients was significantly higher than that of nonazoospermic (P < 0.05). However, there was no significant difference between the two groups in terms of the detection of L. monocytogenes (P > 0.05). Detection of C. trachomatis and L. monocytogenes had no significant association with abnormal semen parameters in asymptomatic patients (P > 0.05). Conclusions: The results indicated that precise analysis of semen parameters and diagnosis of leukocytospermia in patients using the PCR can be considered as a rapid and accurate technique to detect bacteria such as C. trachomatis and L. monocytogenes in semen specimens. Therefore, the utilization of this technique in the screening programs for asymptomatic infertile couples can be helpful for early treatment.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Chlamydia trachomatis and Listeria monocytogenes in Infertile Men and the Effect on Semen Parameters

Tohidpour

Shahhosseiny

Mehrabian

et al. 2020

Jundishapur J Microbiol

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“…Pacchiarotti et al [9] found the presence of antichlamydia antibodies in both the serum and follicular uid reduced the number of mature oocytes in antibodies-positive group, leading to the poor IVF outcome. On the contrary, some studies demonstrated that previous CT infection does not affect pregnancy outcomes in IVF/ICSI (11)(12)(13)17). Claman et.al [18] showed no differences in pregnancy rates or outcomes in patients with and without serologic evidence of previous CT infection.…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that abnormal immune induced by persistent CT infection might promote tubal damage and have impact on IVF/ICSI outcomes. On the other hand, some studies found that there was no signi cant difference in outcomes of IVF/ICSI between patients with CT infection and those without infection [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Effect of Previous Chlamydia Trachomatis Infection on the Outcomes of IVF/ICSI Treatment: A retrospective study

Zhang

Wang

et al. 2022

Preprint

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Background: The impact of Chlamydia trachomatis infection (CT) on the outcomes of In-Vitro Fertilizition / Intracytoplasmic sperm injection (IVF/ICSI) has been controversial. Methods: This retrospective study investigated the effect of cured CT infection and the intervals between infection and the first embryo transfer on pregnancy outcomes in infertile patients undergoing IVF/ICSI. A total of 431 infertility women aged 20-38 years with or without Chlamydia trachomatis infection before fresh/ frozen embryo transfer were included. We subdivided the infected group into two subgroups for ≤ 3 months and > 3 months according to the different intervals between Chlamydia trachomatis positive testing and embryo transfer. The effect of chlamydia infection and the intervals between infection and embryo transfer on pregnancy outcomes was analyzed. Results: Our results revealed that implantation rate was significantly lower and the premature rupture of membranes (PROM) was higher in women with CT infection than non-infection. The multivariate logistic regression analysis adjusting for baseline characteristics showed no significant difference in embryo implantation between neither two groups nor two subgroups while patients in infection group have higher rate of PROM than those in control group.Conclusions: The study suggests that previous Chlamydia trachomatis infection would not impair embryo implantation but lead to high risk of PROM and the intervals between infection and embryo transfer would not impact the pregnancy outcomes of IVF/ICSI.

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“…A population-based study focused on age 20 to 44 in China found the risk factors of CT infection among men included the unprotected sex with commercial sex worker and having recent sex with their spouses or other steady partner; among women, risk factors were living in city and having a spouse or other steady sexual partner who earned a high income; less education was the some risk factors for men and women [40] . Another study focused on the sub-fertile patients found that the age group between 26 to 35 years old had the highest-risk of infection with CT, and both partners were infected in about one third of the couples [41] . Using methods other than condom and having adverse pregnancy history significantly associated with CT infection [20] .…”

Section: Discussionmentioning

confidence: 99%

Ureaplasma urealyticum and chlamydia trachomatis among general married migrants in three cities of China: a workplace-based study

Li¹,

Zhou²,

Xu³

et al. 2019

Preprint

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Background Genital tract infections with ureaplasma urealyticum (UU) and chlamydia trachomatis (CT) are the most frequent sexually transmitted infections (STIs). The aim of this study is to understand the prevalence of UU and CT among general internal married migrants and to explore some possible influencing factors, so as to provide some evidences for STIs prevention in China. Methods A cross-sectional study was conducted in three cities of China from March 2016 to February 2017. A total of 3180 internal-married migrants were included. The structured questionnaire survey, gynecological or andrology examination and laboratory detection were conducted by the trained research fellow s. The prevalence of UU and CT was laboratory-confirmed in this study. Results The prevalence of laboratory-confirmed UU and CT were 45.41%, 5.75%, respectively. The co-infection rate was 4.09%. The rates of UU and CT of Shanghai participants (54.01%, 7.35%) were the highest, and the lowest were that of Yinchuan (37.74%, 4.52%). In Urumqi, the prevalence of UU and CT were 44.77%, 5.42%, respectively, but it has the highest co-infection rate. The multiple stepwise logistic regressions found that the prevalence of UU among three cities were different, and the male’s UU infection was lower than that of women (OR=0.71, 95%CI:0.61-0.83), and the 20-34 age group participants had lower UU and CT risk, compared with that of 45-49 age group. Moreover, the white-collar workers had lower risk of UU infection (OR=0.64, 95%CI: 0.49-0.83), compared with laborer, and using condom could reduce the UU infection (OR=0.74, 95%CI: 0.63-0.87). Compared with urban migrants, the rural participants had higher risk of CT infection (OR=1.68, 95%CI: 1.12-2.52), and sex behavior during menstruation could increase the prevalence of CT (OR=1.49, 95%CI: 1.05-2.11). Conclusion The prevalence of UU and CT were high and the co-infection was also serious among general internal married migrants. More health promotion measures about UU and CT should be taken to help general migrants of China, especially women and those with lower social-economic status (laborers from rural area), risky sexual behaviors such as having sex during menstruation should be warned of and condom-use should be promoted.

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Comparative study in infertile couples with and without Chlamydia trachomatis genital infection

Cited by 10 publications

References 21 publications

Prevalence of Chlamydia trachomatis and Listeria monocytogenes in Infertile Men and the Effect on Semen Parameters

Prevalence of Chlamydia trachomatis and Listeria monocytogenes in Infertile Men and the Effect on Semen Parameters

Effect of Previous Chlamydia Trachomatis Infection on the Outcomes of IVF/ICSI Treatment: A retrospective study

Ureaplasma urealyticum and chlamydia trachomatis among general married migrants in three cities of China: a workplace-based study

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