Comparative Study between the Efficacy of Intradermal Injection and Oral Administration of Tranexamic Acid in Treatment of Melasma

Ebrahim, A.A.; Mustafa, A.I.; Saba, Marian

doi:10.21608/bjas.2020.135710

Cited by 2 publications

(3 citation statements)

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“…In contrast, Ebrahem et al reported no significant difference between TXA mesotherapy (4 mg/cc) and TXA mesoneedling with 6 bimonthly sessions regarding mMASI and patients’ assessment. Irritation (19.6%) was only reported in mesoneedling group 26 …”

Section: Discussionmentioning

confidence: 93%

“…Therefore, TXA inhibits angiogenesis by suppression of VEGF, endothelin (ET)‐1, and IL‐8, while reducing the number of mast cells. It also causes competitive inhibition of tyrosinase (an important enzyme in melanogenesis) 7–33 …”

Section: Discussionmentioning

confidence: 99%

“…Injections were performed at 1 mm depth and 1 cm distance by 28–30‐gauge insulin syringe. Follow‐up periods were between 1 and 12 months 7–33 . Based on published articles, significant reductions in melasma area and severity index (MASI) scores were reported with TXA mesotherapy, from 33.3% to 81.2%.…”

Section: Discussionmentioning

confidence: 99%

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Safety and efficacy of mesotherapy in the treatment of melasma: A review article

Khalili

Amiri

Iranmanesh

et al. 2021

J of Cosmetic Dermatology

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Background Mesotherapy is a popular novel therapeutic modality that is defined as intradermal or subcutaneous microinjection of pharmaceutical compounds. Although this novel treatment method is used commonly in aesthetic dermatology, there is little information about details of injections, efficacy, and side effects of mesotherapy in melasma. Aim In this review, we evaluated efficacy and safety of various types of mesotherapy in the treatment of melasma. Method We searched Google Scholar, Medline, and PubMed for related articles with keywords “melasma” OR “chloasma” AND “mesotherapy” OR “injection.” Inclusion criteria were articles that evaluated intradermal injection of lightening drugs and published dates between January 2000 and September 2021. Exclusion criteria were articles in languages other than English or non‐human studies. Results Thirty‐three articles evaluated efficacy of mesotherapy in melasma, including 28 articles about tranexamic acid, 4 articles about vitamin C, 2 articles about glutathione, and 2 articles about triamcinolone. Conclusion Mesotherapy is a good alternative or adjunctive choice in patients who are refractory to first‐line therapy, patients with low compliance with everyday use of topical therapy, patients with contraindication to oral tranexamic acid therapy, or who wish short downtime and fast recovery period. Further studies with large sample sizes are required to determine ideal concentrations of mesotherapy substances and intervals between sessions and to evaluate the efficacy of different substances for mesotherapy as monotherapy compared to combination therapy and other treatment modalities for melasma.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%