Comparative study between ⁶⁸Ga‐prostate‐specific membrane antigen positron emission tomography and conventional imaging in the initial staging of prostate cancer

Abstract

The use of Ga-PSMA PET scans in initial staging can have a significant impact on staging and management when compared to current conventional imaging modalities.

Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Compared with Conventional Imaging for Initial Staging of Treatment-naïve Intermediate- and High-risk Prostate Cancer: A Retrospective Single-center Study

“…In this setting, PSMA PET/CT is changing the 44 approach to recurrent PCa evaluation and management 45 [13,14]. high-risk (HR) PCa are limited [15][16][17][18][19]. In this study, we…”

Behandlung des Primärtumors beim oligometastasierten Prostatakarzinom

“…Eine Cholin-PET oder eine PSMA-PET waren nicht verfügbar. Darüber hinaus ist der Stellenwert der PET zur Diagnose einer "niedrigen Metastasenlast" unbekannt [29,30], daher sollte die Indikation zur lokalen Therapie streng nach CT-, MRT-und Skelettszintigrafie-Kriterien gestellt werden [25].…”

Oligometastatic prostate cancer: Reality or figment of imagination?

“…Radiotracers targeted to prostate‐specific membrane antigen (PSMA) also have produced encouraging results and make rational sense, because this transmembrane protein is widely expressed by prostate cancer cells . It is noteworthy that, in a retrospective review of 21 patients who had de novo metastatic disease with ≤3 metastases on conventional imaging, 68 gallium ( 68 Ga)‐PSMA PET downstaged 12 to localized disease and upstaged 1 to polymetastatic disease . Given such data, consideration should be made to the inclusion of newer functional imaging strategies as a component of screening or investigational endpoints on prospective protocols for oligometastatic prostate cancer, as was done in 8 of the 21 protocols (39%) listed in Table…”

“…73 It is noteworthy that, in a retrospective review of 21 patients who had de novo metastatic disease with ≤3 metastases on conventional imaging, 68 gallium ( 68 Ga)-PSMA PET downstaged 12 to localized disease and upstaged 1 to polymetastatic disease. 89 Given such data, consideration should be made to the inclusion of newer functional imaging strategies as a component of screening or investigational endpoints on prospective protocols for oligometastatic prostate cancer, as was done in 8 of the 21 protocols (39%) listed in Table 2 In the de novo oligometastatic setting, one more commonly investigated treatment approach is local ablative therapy to the prostate with or without pelvic lymph nodes and without metastasis-directed therapy. 90 Until recently, support for this strategy has been extrapolated from retrospective series that included patients with unselected metastatic burden.…”