Comparative study between immunoturbidimetric and latex agglutination methods for the detection of rheumatoid factor

Rocha, Katya Cristina; Brinque, Luiz Alberto da Fonseca; Oliveira, Claudia Giorgia Bronzatti de; Sant'Anna, Aleksandra Vanessa Lambiasi; Fonseca, André; Azzalis, Ligia Ajaime; Pereira, Edimar Cristiano; Junqueira, Virgínia Berlanga Campos; Beltrame, Registila Libania; Fonseca, Fernando Luiz Affonso

doi:10.1590/s1676-24442013000100002

Cited by 5 publications

(1 citation statement)

References 18 publications

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“…The occurrence and prevalence of rheumatoid arthritis was shown to be age-dependent with a 2% lower incidence in younger than in aged population (up to 70 years) . After the age of 70 years, the incidence of RA starts to decline [15].…”

Section: Introductionmentioning

confidence: 99%

Correlation the Cytomegalovirus (CMV) IgM Antibodies and Viral DNA Presence with Rheumatoid Arthritis (RA) in Iraqi Patients

Fadhil

2019

eijs

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In the Iraqi population, a high incidence (82.7%) of rheumatoid arthritis (RA) has been reported among the suspected patient. Many investigators studied the microbial infectious present in Iraqi patients with RA; however, to the best of our knowledge, there is no previous study detected the CMV DNA and antibodies to RA disease. Hence, the current study aimed to investigate the presence of CMV DNA and antibodies in Iraqi RA patients. A total of 58 blood samples were collected from patients with clinical signs of rheumatoid arthritis, along with 32 samples of apparently healthy individuals as a control group. These samples were tested for rheumatoid factor (RF), CMV IgM antibodies and viral DNA during the acute and the chronic periods of the autoimmune disease. The results showed that 46.6% (27/58) and 13.8% (8/58) of rheumatoid arthritis patients had positive reactions for IgM-CMV and CMV DNA, respectively, as compared to healthy individual. The highest rate of the viral occurrence was recorded in the aged and female RA patients (24 and 21 cases, respectively). Moreover, the most significant increases in RA appearance and CMV reactivation cases were observed in patients with a mean age higher than 40 years old. This finding pointed out the prevalence of viral infections mostly in RA patients aged more than 40 years old, accompanied by increased RA cases. This study concludes that patients with positive CMV must be tested for rheumatoid factor, especially when the viral DNA is present. Moreover, we recommend measuring TNF-Î± and IFN-Î³ as the proinflammatory cytokines that play an important role to protect against viral infection and prevent their reactivation in all RA patients.

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Section: Introductionmentioning

confidence: 99%

Correlation the Cytomegalovirus (CMV) IgM Antibodies and Viral DNA Presence with Rheumatoid Arthritis (RA) in Iraqi Patients

Fadhil

2019

eijs

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Potential prognostic value of rheumatoid factor in anti-aquaporin 4-immunoglobin G-positive neuromyelitis optica spectrum disorders

Lee,

Seok,

Hwang

et al. 2024

Journal of the Neurological Sciences

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Functional promoter polymorphisms of the receptor for advanced glycation end products in children and adolescents with type 1 diabetes

Gomes

Welter

Gobor

et al. 2015

Molecular and Cellular Probes

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Comparative study between immunoturbidimetric and latex agglutination methods for the detection of rheumatoid factor

Abstract: Estudo comparativo entre as técnicas de aglutinação em látex e de imunoturbidimetria para a detecção de fator reumatoide

Cited by 5 publications

References 18 publications

Correlation the Cytomegalovirus (CMV) IgM Antibodies and Viral DNA Presence with Rheumatoid Arthritis (RA) in Iraqi Patients

Correlation the Cytomegalovirus (CMV) IgM Antibodies and Viral DNA Presence with Rheumatoid Arthritis (RA) in Iraqi Patients

Potential prognostic value of rheumatoid factor in anti-aquaporin 4-immunoglobin G-positive neuromyelitis optica spectrum disorders

Functional promoter polymorphisms of the receptor for advanced glycation end products in children and adolescents with type 1 diabetes

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