Comparative study between efficacy of magnesium sulphate and lignocaine in attenuating haemodynamic response to laryngoscopy and endotracheal intubation

Hossain, Mpa; Islam, Md. Saiful; Chowdhury, MH; Ahmed, Masud; Haque, Mozibul; Aleem, MA; Chowdhury, JP

doi:10.3329/jafmc.v8i1.13533

Cited by 3 publications

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“…20,21 The results of our study were similar to a local study done by Waseem SHM et al which concluded that Lidocaine was more effective in controlling stress response to intubation than Magnesium Sulphate. 10 Contrary to this, Hossain et al 22 and Batata et al, 23 concluded that Magnesium Sulphate was superior to Lidocaine with respect to MAP control.…”

Section: Discussionmentioning

confidence: 95%

Blunting Stress Response During Intubation in Hypertensive Patients; A Comparison Between Lidocaine and Magnesium Sulphate

Feroze¹,

Hussain²,

Naseer³

2022

PAFMJ

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Objective: To compare blunting of hemodynamic stress response to intubation using Magnesium Sulphate versus Lidocaine in hypertensive patients. Study Design: Prospective comparative study. Place and Duration of Study: Anaesthesia Department Combined Military Hospital, Lahore Pakistan, from Jan to Jun 2019. Methodology: A total of 232 hypertensive patients of the ASA status II, undergoing elective surgical procedures requiring intubation, were randomly divided into two groups, Group-L (Lidocaine) and Group-M (Magnesium Sulphate). Lidocaine 1.5mg/kg was given to Group-L 90 seconds before laryngoscopy, whereas Magnesium Sulphate 30mg/kg was given over ten minutes to Group-M before laryngoscopy. Baseline means arterial pressure was recorded. Mean arterial pressure was subsequently recorded each minute after intubation for five minutes. Results: Both groups were similar with regard to demographic data. After intubation, both groups had an increase in mean arterial pressures. Blunting of stress response was observed in 78 patients (67.2%) in Group-L and 55 patients (47.4%) in Group-M. Two groups showed a significant statistical difference (p=0.003).Conclusion: Both drugs are effective in blunting hemodynamic stress response to intubation in hypertensive patients, but Lidocaine is more effective than Magnesium Sulphate.

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Section: Discussionmentioning

confidence: 95%

Blunting Stress Response During Intubation in Hypertensive Patients; A Comparison Between Lidocaine and Magnesium Sulphate

Feroze¹,

Hussain²,

Naseer³

2022

PAFMJ

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“…24 Likewise Hossain et al in their comparative study between the efficacy of magnesium sulphate and lignocaine in attenuating haemodynamic response to laryngoscopy and endotracheal intubation published in Journal of Armed Forces Medical College, Bangladesh showed that IV MgSO4 (50 mg/kg) is superior to IV Lignocaine (1.5 mg/kg) for attenuation of haemodynamic response to laryngoscopy and ET intubation. 25 However we have not done comparative study using lignocaine.…”

Section: Discussionmentioning

confidence: 97%

The effects of magnesium sulphate on haemodynamic stress response to pneumoperitonium in laparoscopic cholecystectomy: a double blinded randomised controlled study

et al. 2021

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Background: To study the effect of intravenous magnesium sulphate on hemodynamic response to pneumoperitoneum during laparoscopic cholecystectomy and to study the side effects of the drug of any.Methods: Patients were randomly allocated into two groups of 40 each. Automated NIBP, Heart rate, Nausea, headache was noted. Magnesium ion concentration was measured. Chi square test was used to test the association between different study variables under study. Corrected test was used in case of any one of the cell frequency was found less than 5 in the bivariate frequency distribution. Fisher’s Exact Test was also used in the case where the test could not be applied. Test of proportion (Z-test) was used to test the significant difference between two proportions. t-test was used to test the significant difference between means. P≤0.05 was considered statistically significant.Results: Patients’ characteristics were comparable in both groups. Most data related to surgery and anaesthesia were comparable in both groups. The MAP of group N (control) was significantly higher than that of group M throughout surgery (P5,P10,P20,P30, and at extubation) except at baseline and at the time of PP (P0). The MAP is better maintained in M group. Usage of GTN in the control group was significantly higher. HR of the control group was significantly higher after 20 min (P20) of pneumoperitoneum and after extubation. There was significantly more incidence of nausea and vomiting in the control group.Conclusions: Use of magnesium sulphate just before pneumoperitoneum is very useful for attenuating haemodynamic alterations to pneumoperitoneum and the requirement of antihypertensive GTN is significantly much less compared to the control group during laparoscopic surgery without increasing any adverse outcome.

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Effect of Intravenous Magnesium Sulphate and Lidocaine on Hemodynamic Response to Laryngoscopy and Endotracheal Intubation

Paudel¹,

Yadav²,

Thapa³

et al. 2022

ijsr

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Introduction:Laryngoscopy and endotracheal intubation is associated with sympathetic stimulation leading to increase in heart rate and blood pressure. We have compared the efcacy of Magnesium sulphate and Lidocaine in blunting the hemodynamic response to laryngoscopy and tracheal intubation as well as the side effects of the drugs. Materials and methods:We conducted a double blinded, prospective, randomized study performed on total of 80, ASAI and II patients who were divided into group M, receiving 30mg/kg Magnesium sulphate, and group L receiving 1.5mg/kg Lidocaine, before laryngoscopy and intubation. Changes in hemodynamic variables like Heart rate(HR), Systolic blood pressure(SBP), Diastolic blood pressure(DBP), and Mean arterial pressure (MAP) were recorded at various time intervals such as at pre anesthetic baseline, before induction, 1min, 3 min, 5 min, and 10 min post intubation. Patients were also observed for adverse effects of the drugs used. Results:Demographic parameters were comparable in terms of age, weight, ASA, distribution of gender. Baseline HR, SBP, DBP, and MAP were similar and insignicant (p-value>0.05) when the two groups were compared. There was signicant rise in HR in Lidocaine group as compared to Magnesium group at 1min,3min post-intubation(p-value<0.05). Signicant attenuation of BPwas seen with Magnesium as compared to Lidocaine at 1min, 3min, 5min post-intubation(p-value<0.05).No adverse effects of drugs were observed during the study. Conclusion: Though Lidocaine and Magnesium both attenuated the hemodynamic response to laryngoscopy and intubation, Magnesium was found to control hemodynamic changes better than Lidocaine. And at the dosage of drugs we used there were no adverse effects.

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Comparative study between efficacy of magnesium sulphate and lignocaine in attenuating haemodynamic response to laryngoscopy and endotracheal intubation

Abstract: DOI: http://dx.doi.org/10.3329/jafmc.v8i1.13533 JAFMC Vol.8(1) 2012 pp.15-19

Cited by 3 publications

References 0 publications

Blunting Stress Response During Intubation in Hypertensive Patients; A Comparison Between Lidocaine and Magnesium Sulphate

Blunting Stress Response During Intubation in Hypertensive Patients; A Comparison Between Lidocaine and Magnesium Sulphate

The effects of magnesium sulphate on haemodynamic stress response to pneumoperitonium in laparoscopic cholecystectomy: a double blinded randomised controlled study

Effect of Intravenous Magnesium Sulphate and Lidocaine on Hemodynamic Response to Laryngoscopy and Endotracheal Intubation

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