Comparative studies, synthesis, spectroscopic and characterization of N-methylisatin-3-Girard’s T and P hydrazone complexes

Azhari, Shaker J.; Salah, S. H.; Farag, Rabei S.; Mostafa, Mohsen M.

doi:10.1016/j.saa.2014.10.106

Cited by 6 publications

(7 citation statements)

References 34 publications

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“…Such hydrazones can be coordinated in non deprotonated form as cationic ligands or can be deprotonated forming formally neutral zwitter-ions. The presence of additional donor atoms in these ligands allows formation of stable metal chelates and dictates their geometry [34][35][36][37]. The azide anion acts as an inhibitor of cytochrome oxidase, mitochondrial F ATP-ase [38] and antioxidant enzymes catalase [39], peroxidase [40] and superoxide dismutase [41].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure, magnetic properties and DFT study of dinuclear Ni(II) complex with the condensation product of 2-quinolinecarboxaldehyde and Girard’s T reagent

et al. 2017

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A dinuclear double end-on azido bridged Ni(II) complex [Ni 2 L 2 (μ-1,1 -N 3 ) 2 (N 3 ) 2 ] (1) with the condensation product of 2-quinolinecarboxaldehyde and trimethylammonium acetohydrazide chloride (Girard's T reagent) (HLCl) has been synthesized and characterized by elemental analysis, IR spectroscopy, single-crystal X-ray diffraction, magnetic measurements and DFT studies. In complex 1 intra-dimer ferromagnetic coupling between Ni 2+ ions (J = +12.0(2) cm -1 ) and inter-dimer antiferromagnetic interaction (δ = -0.8(3) cm -1 ) were observed. DFT-BS calculations provided explanation of ferromagnetic exchange coupling in complex 1.

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Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure, magnetic properties and DFT study of dinuclear Ni(II) complex with the condensation product of 2-quinolinecarboxaldehyde and Girard’s T reagent

et al. 2017

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“…The v(C=N) band, which was found at 1550–1590 cm −1 in free ligands, shifted to a lower frequency in metal complexes, showing coordination with the >C=N– group (Table S2). 71,72 The metallic complexes also showed a non‐ligand band in the range 480–522 cm −1 and 445–476 cm −1 , which is stated to ν (M–O) and ν (M–N) stretching vibrations, respectively 20,38,64 …”

Section: Resultsmentioning

confidence: 96%

Synthesis, spectroscopic, molecular docking, theoretical calculations, DNA‐binding, and anticancer activity studies of gold (III), platinum (II), palladium (II), and ruthenium (III) complexes with Girard‐T reagent

Al‐Radadi,

El‐Gamil

2023

Applied Organom Chemis

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This article details the synthesis of new Girard‐T reagent ligands. Condensation of 2‐hydroxyacetophenone or 2‐acetyl‐thiophene with Girard‐T reagent results in new hydrazone ligands. The interaction of these Girard‐T hydrazones with transition metal chlorides, like Au (III), Ru (III), Pd (II), and Pt (II), produces different complexes. Elements and spectrum analyses (IR, UV–Vis, EI‐mass, and 1H NMR) were used to characterize the isolated solid complexes, as well as conductimetric and magneto‐chemical studies. Metal complexes can have different geometrical configurations, including square planar and octahedral coordination. The DMOL3 method, which is a part of the Material Studio package, was also utilized for structure optimization. Horowitz–Metzger and Coats–Redfern methods were utilized to calculate the various thermodynamic and kinetic parameters. The ligands and the complexes of their metal were evaluated for anticancer activity against carcinoma cervix (Prostate) and the mammary gland female breast (MCF‐7) cell line having cancer, with promising results. Among these compounds, the Ru (III) and Pt (II) complexes' anticancer activity against (MCF‐7) cell lines, comparable with that of 5‐fluorouracil were carried out and their interactions were performed by molecular docking simulations against MCF‐7 (PDB ID: 3W2S) receptor.

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“…The ESI-MS (+) and elemental analysis of Fe-L proved that the ratio of the ligand to the metal ion is 1:2 with m/z: 641.85 due to [Fe(NO 3 ) 2 + L + 2H 2 O+6CH 3 OH] + , The complex formed via coordination between carbonyl and imine groups with the metal ion. IR data showed decreasing of stretching vibration frequencies of donating groups (ῡ C = O 1719 → 1604), (ῡ C = N 1616 → 1573), the broad band around 3300 due to OH of water moiety coordinated with Fe with expected octahedral structure (Azhari, Salah, Farag, & Mostafa, 2015).…”

Section: Description Of Complexes Structuresmentioning

confidence: 98%

Synthesis, molecular docking and computational studies of novel hydrazone complexes

Salah

Kandil

El-Nasser

2019

Journal of Radiation Research and Applied Sciences

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In this study, a hydrazone ligand complexes based on p-anisidine and acetylacetone derivatives with transition metals like Ni, Cu, Fe, and Zr were prepared. The structure of the prepared compounds was confirmed using Nuclear magnetic resonance (1 H-NMR and 13 C-NMR), Distortionless enhancement by polarization transfer (DEPT), heteronuclear single quantum coherence (HSQC-NMR), Correlated Spectroscopy (COSY-NMR), Fourier-transform infrared spectroscopy (FT-IR) and Electrospray ionization mass spectrometry (ESI-MS). The x-ray single crystal of the ligand was studied and the results showed that an intramolecular N-H. .. .O = C hydrogen bond (1.87Å) exists that stabilizes the geometrical structure of the ligand. Also, the magnetic properties for the prepared complexes were studied using Gouy's method of susceptibility measurement. In addition, there in silico docking and In vitro antibacterial activities were investigated and the results showed that Fe complex has the highest antimicrobial activity. The expected structures and conformers for the prepared ligands and complexes were examined and fully optimized using the level B3LYP/6-31G*.

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Comparative studies, synthesis, spectroscopic and characterization of N-methylisatin-3-Girard’s T and P hydrazone complexes

Cited by 6 publications

References 34 publications

Synthesis, crystal structure, magnetic properties and DFT study of dinuclear Ni(II) complex with the condensation product of 2-quinolinecarboxaldehyde and Girard’s T reagent

Synthesis, crystal structure, magnetic properties and DFT study of dinuclear Ni(II) complex with the condensation product of 2-quinolinecarboxaldehyde and Girard’s T reagent

Synthesis, spectroscopic, molecular docking, theoretical calculations, DNA‐binding, and anticancer activity studies of gold (III), platinum (II), palladium (II), and ruthenium (III) complexes with Girard‐T reagent

Synthesis, molecular docking and computational studies of novel hydrazone complexes

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