Comparative studies on the pyrolysis of N‐arylideneaminoamides: Kinetic and mechanistic studies

Abstract

Rates of thermal decomposition of title compounds have been measured using a static reaction system. They undergo a unimolecular first-order elimination to give arylnitrile and the corresponding substituted amides. The decomposition parallels that of Narylidenamino cyclic amide. The relative elimination rates at 600 K were calculated. The kinetic data reveal that the electronic effects of substituents, such as methyl, phenyl, benzyl, and allyl groups, are associated with the opposing directions in which the lone pair of electrons on the nitrogen atom of the arylidene moiety is being delocalized.

Synthesis and Biological Evaluation of 4‐Phenoxy‐6,7‐disubstituted Quinolines Possessing Semicarbazone Scaffolds as Selective c‐Met Inhibitors

“…Compound 43 was afforded by reduction of the double bond in imine using (CH 3 COO) 3 BHNa in THF and acetic acid at room temperature . In the following work, compound 35 reacted with CH 3 I in the presence of NaH to give compound 44 in moderate yield .…”

Kinetics and mechanism of gas‐phase pyrolysis of ylides. Part 3.1 Thermal reactivity of α‐carbonyl‐ and thiocarbonyl‐stabilized methylenetriphenylphosphoranes

“…A minimum of three kinetic runs were carried out at each reaction temperature following each 10–15 °C rise in the pyrolyzer temperature to ensure reproducible values of ( A ). Treatment of the kinetic data and calculation of Arrhenius parameters and reaction rate constants have been detailed elsewhere 44. The experimental conditions for kinetic and HPLC analysis of the ylides 1 – 4 are summarized in Table 2.…”

Gas-Phase Pyrolytic Reaction of 4-Aryl-3-buten-2-ols and Allyl Benzyl Ethers: Kinetic and Mechanistic Study

“…Allylbenzene ( 8e . LCMS: m/z = 119 (M + 1); 1 H-NMR (CDCl 3 ): δ 3.46 (d, 2H, J = 6.2 Hz), 5.17 (m, 2H), 6.05 (m, 1H), 7.27 (d, 2H, J = 7.8 Hz ), 7.39 (t, 2H, J = 7.8 Hz ), 7.45(t, 1H, J = 7.8 Hz) [ 22 ].…”

“…A minimum of two kinetic runs were carried out at each reaction temperature following each 10 °C rise in the pyrolyzer temperature to ensure reproducible values of (A). Treatment of the kinetic data and calculation of Arrhenius parameters and reaction rate constants have been detailed elsewhere [ 22 ]. Figure 2 shows Arrhenius plot for pyrolysis of compounds 5b as a selected example.…”