Comparative Studies on the Pattern of Infection with Giardia spp. in Mongolian Gerbils

Faubert, G M; Belosevic, Miodrag; Walker, T S; MacLean, J D; Meerovitch, E.

doi:10.2307/3281033

Cited by 39 publications

(22 citation statements)

References 13 publications

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“…As shown in Figure 2, only the positive control group and gerbils receiving concentrated primary effluent developed an infection, demonstrating the presence of infectious cysts in the primary-effluent sample. As is typical in gerbils infected with G. lamblia (Faubert et al, 1983), cyst counts were highly variable as reflected by the high standard deviations.…”

Section: Resultsmentioning

confidence: 87%

Giardia Cysts in Tertiary‐Treated Wastewater Effluents: Are They Infective?

Garcia¹,

Yanko²,

Batzer³

et al. 2002

Water Environment Research

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The infectivity of Giardia lamblia cysts recovered in primary-and tertiary-treated wastewater reclamation plant effluents was assessed in Mongolian gerbils (Meriones unguiculatus). Infections in gerbils inoculated with cysts from primary effluent concentrates demonstrated the presence of infectious G. lamblia cysts. No infectious cysts were detected by this method in concentrates of tertiary-treated effluents. This study found that determination of cyst concentrations without viability or infectivity assessment may significantly overestimate the potential health risks associated with protozoan cysts in tertiarytreated wastewater effluents. Water Environ. Res., 74, 541 (2002).

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Section: Resultsmentioning

confidence: 87%

Giardia Cysts in Tertiary‐Treated Wastewater Effluents: Are They Infective?

Garcia¹,

Yanko²,

Batzer³

et al. 2002

Water Environment Research

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“…Giardiasis is produced by the ingestion of cysts which undergo transformation into flagellate trophozoites exhibiting specific tropism for the proximal small intestine where they attach t o the mucosal surface or exist free in the intestinal lumen. A high degree of immunity to re-infection after clearance of a primary infection exists in experimental animals (Roberts-Thomson et al 1976b, Faubert et al 1983 al. 1984), yet the mechanisms involved in clearance of Giardia from the intestine are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Biliary antibody response in rats infected with rodent Giardia duodenalis isolates

Sharma

Mayrhofer

1988

Parasite Immunology

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Using a sensitive ELISA, specific serum and bile anti-Giardia IgM and IgA responses were studied in rats infected with two strains of Giardia duodenalis: a rat isolate which produces a chronic infection and a mouse isolate which produces a self-limiting infection. Paired samples of serum and bile were collected from groups of DA (RT1avl) rats at various times during primary and secondary infections. Antibody responses to both organisms were similar. Only IgA anti-Giardia antibodies were detected in bile whereas both IgM and IgA antibodies were detected in serum. Biliary IgA antibody titres increased throughout the course of the primary infection and remained at high levels for at least 10 weeks. Biliary IgA titres increased 16-fold during the secondary infection with both isolates. Serum IgA anti-Giardia titres also increased but more slowly than the titres in bile. Serum IgM antibody responses were observed against both organisms during the primary and secondary infections. Trophozoites harvested from the intestinal lumen during primary infections were examined for surface-bound IgA by immunofluorescence microscopy. IgA was detected on 3% of trophozoites on day 7 after infection but on over 70% of trophozoites by the 10th day. The data demonstrate the occurrence of a secretory IgA immune response in rats infected with both G. duodenalis isolates, some of which is directed against surface antigens of the trophozoites.

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“…Experimental protozoal infections include Giardia lamblia Faubert et al, 1983) and the cattle piroplasm Babesia divergens (Dkhil et al, 2013;Lewis and Williams, 1979;Lewis et al, 1981). Experimental protozoal infections include Giardia lamblia Faubert et al, 1983) and the cattle piroplasm Babesia divergens (Dkhil et al, 2013;Lewis and Williams, 1979;Lewis et al, 1981).…”

Section: Use In Researchmentioning

confidence: 99%