Comparative Studies on the Effect of Corynebacterium parvum on Bone-Marrow Cell Colony Formation in Vitro

Nonspecific immunotherapy with monthly intramuscular (IM) injections of Corynebacteriurn parvurn has been investigated in patients with disseminated melanoma. Forty-nine patients were randomized to receive either imidazole carhoxamide (DTIC) alone or DTIC plus C parvurn. A 24% overall objective response rate was observed, with no significant difference between the response rate or survival of the two treatment groups. Immunologic studies revealed no significant difference between the two groups. One patient undergoing chemoimmunotherapy demonstrated profound pancytopenia which responded to cessation of therapy, but toxic reactions were otherwise minimal. No advantage was obtained by adding IN1 injected C parvum to standard chemotherapy in the treatment of disseminated melanoma. Cancer 46:475-479, 1980.

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A trial of imidazole carboxamide and corynebacteriumparvum in disseminated melanoma. Clinical and immunologic results

Clunie

Gough

Dury

et al. 1980

Cancer

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A trial of 5-fluorouracil and Corynebacterium parvum in advanced colorectal carcinoma

Gough

Clunie

Bolton

et al. 1979

Diseases of the Colon &Amp; Rectum

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This study has confirmed that patients who have advanced colorectal carcinoma have impaired responsiveness to delayed-hypersensitivity skin testing, and also have elevated levels of serum IgM. Serial observations of delayed-hypersensitivity skin tests, total lymphocyte counts, T-lymphocyte counts, B-lymphocyte counts, and serum immunoglobulin levels failed to reveal any consistent pattern of responses in patients treated with either chemotherapy alone or chemoimmunotherapy. In 33 patients chosen at random to receive either 5-FU alone or 5-FU in combination with intramuscularly administered C. parvum, there was no evidence of objective response or influence on survival. Intramuscularly administered C. parvum, in the dose and schedule used, produced no evident immunologic or therapeutic effect.

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Effect of Corynebacterium parvum stimulation on granulopoiesis

Eliopoulos

Andre

Meletis

et al. 1980

European Journal of Cancer (1965)

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Comparative Studies on the Effect of Corynebacterium parvum on Bone-Marrow Cell Colony Formation in Vitro

Cited by 5 publications

References 16 publications

A trial of imidazole carboxamide and corynebacteriumparvum in disseminated melanoma. Clinical and immunologic results

A trial of imidazole carboxamide and corynebacteriumparvum in disseminated melanoma. Clinical and immunologic results

A trial of 5-fluorouracil and Corynebacterium parvum in advanced colorectal carcinoma

Effect of Corynebacterium parvum stimulation on granulopoiesis

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