Comparative Studies on Optical Biosensors for Detection of Bio-Toxins

Nabok, Alexei

doi:10.1007/978-3-319-28926-7_23

Cited by 10 publications

(9 citation statements)

References 32 publications

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“…The experimental set-up for PI biosensor equipped with the reaction cell and inlet and outlet tubes for injection of solutions to be analysed was built and tested [64]. The refractive index sensitivity was evaluated by injecting liquids of different refractive indices (different concentrations of NaCl) and appeared to be of 5300 rad/RIU which is close to that reported for MZ-based biosensors [51].…”

Section: Miniaturisation Of Optical Biosensors: Planar Waveguide Biosmentioning

confidence: 52%

“…interferometers. Several recent developments of such devices proved to be successful [51]; they include dual polarization interferometers [52][53][54], ring-resonators [55], and Mach-Zehnder (MZ) interferometers [52,[56][57][58]. Biosensors based on MZ interferometers are perhaps the most popular devices which combine high sensitivity of detection and portable design [52,[56][57][58].…”

Section: Miniaturisation Of Optical Biosensors: Planar Waveguide Biosmentioning

confidence: 99%

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[INVITED] Novel optical biosensing technologies for detection of mycotoxins

Nabok

Al-Rubaye

Al-Jawdah

et al. 2019

Optics & Laser Technology

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This work reviews our recent progress in development of novel optical methods of detection of mycotoxins in direct assay with either specific antibodies or aptamers. The main method in this work was the total internal reflection ellipsometry (TIRE) combined with LSPR transducers based on gold nano-structures produced by annealing of thin gold films. The gold nano-islands produced were characterised with SEM, AFM, UV-visible absorption spectroscopy, and spectroscopic ellipsometry. The combination of TIRE and LSPR offers superior refractive index sensitivity as compared to traditional UV-vis absorption spectroscopy. The limitations of LSPR related to a short evanescent field decay length can be overcome using small-size bio-receptors, such as halfantibodies and aptamers. The achieved sensitivity of detection of mycotoxins in 0.01ppb level of concentration is sufficient for the use of this method for analysis of agriculture products, food and feed on the presence of mycotoxins. Even higher sensitivity in sub-ppt level was achieved with another optical biosensor developed recently; it is based on optical planar waveguide operating as polarization interferometer (PI). This method is promising for development of portable, highly sensitive, and simple to use biosensors suitable for point-of-need detection of mycotoxins.

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Section: Miniaturisation Of Optical Biosensors: Planar Waveguide Biosmentioning

confidence: 52%

Section: Miniaturisation Of Optical Biosensors: Planar Waveguide Biosmentioning

confidence: 99%

[INVITED] Novel optical biosensing technologies for detection of mycotoxins

Nabok

Al-Rubaye

Al-Jawdah

et al. 2019

Optics & Laser Technology

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“…Therefore, there is a great demand for development of biosensors for toxin detection. Highly sensitive optical immunosensors are leading in this development [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The use of a planar waveguide (PW) operating as a polarization interferometer (PI) [ 7 ] is a logical continuation of this work toward the development of portable sensor devices. The advantages of PW PI devices, due to their thousands of reflections of light, were demonstrated in [ 7 , 8 ], which may lead to the development of highly sensitive optical biosensors capable of label-free detection of toxins [ 3 , 6 ]. Several successful biosensors based on planar waveguides have been demonstrated recently.…”

Section: Introductionmentioning

confidence: 99%

“…An inhibition sensor array based on PW optrodes using enzymes as bioreceptors was capable of detecting traces (in the sub-ppb concentration range) of heavy metals and pesticides in water [ 9 ]. The mainstream development of optical PW-based sensor devices lies in the use of Mach–Zahender (MZ) interferometers [ 10 , 11 , 12 , 13 , 14 ] and ring resonators [ 15 , 16 ], both approaches having demonstrating remarkable refractive index sensitivity around 7000 to 8000 rad/refractive index unit (RIU) [ 3 ] and versatility in their application. The development of a fully integrated all-silicon MZ biosensor [ 17 , 18 , 19 , 20 ] is particularly attractive and may lead to fabrication of portable, highly sensitive optical biosensors suitable for in-field or point-of-care detection of analytes of interest.…”

Section: Introductionmentioning

confidence: 99%

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Mycotoxin Biosensor Based on Optical Planar Waveguide

Al-Jawdah

Nabok

Jarrah

et al. 2018

Toxins

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The research aim of this work is to develop a simple and highly sensitive optical biosensor for detection of mycotoxins. This sensor is built on a planar waveguide operating on the polarization interferometry principle, i.e., detecting a phase shift between p- and s-components of polarized light developed during the binding of analyte molecules. The operation of the proposed sensor is similar to that of a Mach–Zehnder interferometer, while its design is much simpler and it does not require splitting the waveguide into two arms. The refractive index sensitivity of the polarization interferometer sensor was in the range of 5200 radians per refractive index unit (RIU). Several tests were conducted to detect ochratoxin A (OTA) at different concentrations in direct immunoassay with specific antibodies immobilized in the sensing window. The lowest concentration of OTA of 0.01 ng/mL caused a phase shift of nearly one period. The results obtained prove high sensitivity of the sensors, which are capable of detecting even lower concentrations of mycotoxins at the ppt (part-per-trillion) level.

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Ellipsometric biosensors

Çağlayan¹

2023

Fundamentals of Sensor Technology

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Comparative Studies on Optical Biosensors for Detection of Bio-Toxins

Cited by 10 publications

References 32 publications

[INVITED] Novel optical biosensing technologies for detection of mycotoxins

[INVITED] Novel optical biosensing technologies for detection of mycotoxins

Mycotoxin Biosensor Based on Optical Planar Waveguide

Ellipsometric biosensors

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