Comparative studies on novel combinations of pregabalin plus venlafaxine with standard diazepam and marketed combination of alprazolam plus sertraline for anxiety disorders

Abstract

Summary Objective- In present study, eleven novel dose combinations of Pregabalin & Venlafaxine from minimum effective dose to higher anxiolytic dose were taken for assessment of anxiolytic activity in Swiss mice.Method — Classical animal models of anxiety vise: Elevated plus-maze model and Light & Dark Exploration test Apparatus. Diazepam was used as a standard anxiolytic. In addition the combinations were also compared with a fixed dose marketed combination of Alprazolam & Sertraline (Anxit Plus).Result — The results of the study reveal that combinations of Pregabalin & Venlafaxine (serotonin norepinephrine reuptake inhibitor) have better anxiolytic efficacy, which is comparable to Diazepam and Alprazolam-Sertraline combination.Conclusion- Further clinical studies are required for getting better idea about efficacy and clinical utility of Pregabalin-Venlafaxine combination.

The Effect of High Dose and Low Dose Pregabalin as Premedication on Preoperative Anxiety and Sedation Levels

“…In our study PGB was administered 90mins before surgery so that peak plasma levels of PGB has achieved and then sedation and anxiety levels were assessed 19 . In 2018, study revealed that in patients with generalized anxiety disorders (GAD), the chronic use of PGB was significantly more effective than the BDZs (diazepam) in improving anxiety symptoms 20 . Recently in 2019 another study compared PGB 75mg with Alprazolam 0.5mg and concluded that both drugs had equally reduced anxiety 21 .…”