Comparative studies of vertebrate and invertebrate pyruvate kinases

Wu, S.W.N.; Wong, Sin Cheong; Yeung, D.

doi:10.1016/0305-0491(78)90221-3

Cited by 1 publication

(2 citation statements)

References 21 publications

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“…PK is known to be phosphorylated in many systems though primarily in vertebrates and mammals which possess tissue-specific isozymes of which the liver isozyme is highly regulated by phosphorylation (Titanji et al, 1976;Ljungstrom et al, 1976, Eigenbrodt et al, 1977. Phosphorylation of muscle PK is less common and has so far been observed mostly in invertebrates where the presence of tissue-specific isozymes varies widely from species to species (Wu et al, 1978). For instance, the channeled marine whelk muscle tissue exhibits increased phosphorylation of PK in response to anoxia exposure, supposedly responsible for suppressed of the enzyme (Plaxton & Storey 1984b.…”

Section: Discussionmentioning

confidence: 99%

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Regulation of pyruvate kinase in hypometabolic states

Smolinski¹

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Survival in extreme environments requires drastic changes to animals' physiology and biochemistry, requiring many animals to decrease their metabolic rate. Enzymes are the mediators of metabolic functions and their regulation is critical to surviving these conditions. This thesis explores the properties of a key enzyme of glycolysis, pyruvate kinase (PK), in the freeze tolerant wood frog (Rana sylvatica), the anoxia tolerant snail (Littorina littorea) and the hibernating ground squirrel (Urocitellus richardsonii).The studies showed that temperature, allosteric effectors and other local environmental conditions play a role in regulating pyruvate kinase in response to freezing, anoxia and during hibernation. Furthermore, reversible protein phosphorylation appears to be a common regulatory mechanism of PK by reducing the activity of the enzyme in all three animals. Together, these studies show that PK is a common regulatory target of animals surviving in extreme conditions and that multiple regulatory mechanisms, especially protein phosphorylation, contribute to its regulation. iv

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Section: Discussionmentioning

confidence: 99%

“…While some invertebrates like annelids and grasshoppers have been shown to possess multiple isozymes, others express only one, like some sea urchins and snails (Wu et al, 1978). The variety of PK isozymes, their unique kinetic characteristics and their different phosphorylation patterns make PK an even more interesting topic of study.…”

Section: Pyruvate Kinasementioning

confidence: 99%

Regulation of pyruvate kinase in hypometabolic states

Smolinski¹

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Comparative studies of vertebrate and invertebrate pyruvate kinases

Cited by 1 publication

References 21 publications

Regulation of pyruvate kinase in hypometabolic states

Regulation of pyruvate kinase in hypometabolic states

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