Comparative Studies of the Antimicrobial Activity of Components of Different Polarities from the Leaves of Nauclea latifolia

Okiei, W.; Ogunlesi, M.; Osibote, E. A. S.; Binutu, M.K.; Ademoye, Morufu Adisa

doi:10.3923/rjmp.2011.321.329

Cited by 15 publications

(6 citation statements)

References 5 publications

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“…This could be attributed to the presence of tannins which have shown potential antiviral [41], antibacterial [42] and antiparasitic effects [43]. The ethanolic extract of S. latifolus inhibited the growth of E. coli and B. subtilis which was in conformity with what was demonstrated by Okiei et al [44] that ethanolic extract of S. latifolus showed antibacterial property. Isah et al [45] reported also that S. latifolus inhibited the growth of S. typhi, B. subtilis, E. coli, and S. aureus.…”

Section: *Key: ++ = Highly Present + = Slightly Present -= Not Detectedsupporting

confidence: 74%

Phytochemical and in vitro Antibacterial Evaluation of the Ethanolic Extract of the Stem Bark of Entada africana Guill. & Perr and Sarcocephalus latifolus

Ifemeje¹,

Egbuna²,

Udedi³

2014

IJBCRR

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This work was carried out in collaboration between all authors. Author JCI conceived, designed and carried out the phytochemical analysis. Author SCU wrote the protocol and first draft of the manuscript. Authors JCI and CE managed the literature searches, analysed and interpreted the results. Author HII performed the microbial studies. All authors read, corrected and approved the final manuscript.

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Section: *Key: ++ = Highly Present + = Slightly Present -= Not Detectedsupporting

confidence: 74%

Phytochemical and in vitro Antibacterial Evaluation of the Ethanolic Extract of the Stem Bark of Entada africana Guill. & Perr and Sarcocephalus latifolus

Ifemeje¹,

Egbuna²,

Udedi³

2014

IJBCRR

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“…Some of its medicinal effects include antimalarial [ 11 ], antidiabetic [ 8 ], antihypertensive [ 12 – 14 ], antipyretic and antinociceptive [ 15 ], and anti-inflammatory and analgesic activities [ 7 ]. It is also known to have a strong antibacterial property [ 16 , 17 ]. This study was conducted to investigate the antioxidant potentials in the aqueous extracts of the leaves and fruits of Nauclea latifolia as these could be the contributing factors to their health beneficial effects.…”

Section: Introductionmentioning

confidence: 99%

In VitroStudy on the Antioxidant Potentials of the Leaves and Fruits ofNauclea latifolia

Ayeleso

Oguntibeju

Brooks

2014

The Scientific World Journal

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This study was carried out to investigate the in vitro antioxidant potentials of the leaves and fruits of Nauclea latifolia, a straggling shrub or small tree, native to tropical Africa and Asia. Hot water extracts of the leaves and fruits of Nauclea latifolia were assessed for their total polyphenolic, flavanol, and flavonol contents as well as 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging ability, ferric reducing antioxidant power (FRAP), Trolox equivalence antioxidant capacity (TEAC), and oxygen radical absorbance capacity (ORAC) assays. The aqueous extract of the leaves was found to contain higher level of total polyphenols (11.63 ± 0.023 mg GAE/g), flavanol (1.45 ± 0.10 mg CE/g), and flavonol (2.22 ± 0.37 mg QE/g) than the extract of the fruits with values of 1.75 ± 0.02 mg GAE/g (total polyphenol), 0.15 ± 0.01 mg CE/g (flavanol), and 1.00 ± 0.13 mg QE/g (flavonol). Similarly, the aqueous extract of the leaves also exhibited higher DPPH (IC50 20.64 mg/mL), FRAP (86.10 ± 3.46 μmol AAE/g), TEAC (94.83 ± 3.57 μmol TE/g), and ORAC (196.55 ± 0.073 μmol TE/g) than the extract of the fruits with DPPH (IC50 120.33 mg/mL), FRAP (12.23 ± 0.40 μmol AAE/g), TEAC (12.48 ± 0.21 μmol TE/g), and ORAC (58.88 ± 0.073 μmol TE/g). The present study showed that Nauclea latifolia has strong antioxidant potentials with the leaves demonstrating higher in vitro antioxidant activities than the fruits.

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“…Hot aqueous extract also showed effectiveness against chloroquine resistance strains of Plasmodium falciparum (Benoit-Vical et al, 1998). Hot aqueous and ethanolic extracts were demonstrated to exhibit strong anti-bacterial property (Okiei et al, 2011). Alkaloid rich extract of N. latifolia can react in vitro with mammalian DNA, leading to G2-M cell cycle arrest and heritable DNA-damage.…”

Section: Discussionmentioning

confidence: 99%

Anti-ulcer activity of aqueous leaf extract of Nauclea latifolia (rubiaceae) on indomethacin-induced gastric ulcer in rats

Balogun¹,

Oji²,

Besong³

et al. 2013

Afr. J. Biotechnol.

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Nauclea latifolia is known to possess various therapeutic properties. The present study was designed to evaluate the anti-ulcer activity of aqueous leaf extract of N. latifolia against indomethacin-induced gastric ulcers in rats. Five groups of albino rats were pre-treated orally with: vehicle, distilled water (ulcer control), cimetidine (100 mg/kg, reference control), and 170, 340 and 510 mg/kg N. latifolia leaf extracts (experimental groups) respectively, 60 min prior to oral administration of indomethacin to generate gastric mucosal injury. Seven hours later, the animals were sacrificed by a blow on the head; their stomachs were removed and examined for ulcer index. The extract produced significant (P<0.05), and dose dependent anti-ulcer activity against indomethacin-induced ulcers in rats. These results suggest that the extract possesses significant anti-ulcer activity against experimentally induced gastric lesions and may justify its use as an anti-ulcerogenic agent.

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Comparative Studies of the Antimicrobial Activity of Components of Different Polarities from the Leaves of Nauclea latifolia

Cited by 15 publications

References 5 publications

Phytochemical and in vitro Antibacterial Evaluation of the Ethanolic Extract of the Stem Bark of Entada africana Guill. & Perr and Sarcocephalus latifolus

Phytochemical and in vitro Antibacterial Evaluation of the Ethanolic Extract of the Stem Bark of Entada africana Guill. & Perr and Sarcocephalus latifolus

In VitroStudy on the Antioxidant Potentials of the Leaves and Fruits ofNauclea latifolia

Anti-ulcer activity of aqueous leaf extract of Nauclea latifolia (rubiaceae) on indomethacin-induced gastric ulcer in rats

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