Comparative studies of poly(ε-caprolactone) and poly(D,L-lactide) as core materials of polymeric micelles

Abstract

Polymeric micelles have been successfully used to deliver a variety of therapeutic agents. Nonetheless, several limitations and considerations must be clarified and well-studied to achieve the highest therapeutic effect. In this study, a series of methoxy poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL) and methoxy poly(ethylene glycol)-block-poly(D,L-lactide) (PEG-b-PLA) with varying molecular weight (MW) of hydrophobic core segment were synthesized. These block copolymers can form micelle with PCL or PLA as core-forming blocks and PEG as a coronal material. The effect of MW on micelle size and critical micelle concentration (CMC) was studied. DOX (DOX) was encapsulated inside the micelle core. Drug-loading content and size of micelles were studied. Drug release studies inside cells were evaluated by confocal laser scanning microscopy. In summary, the PLA core which is less hydrophobic than PCL showed higher CMC, smaller micelle size and faster DOX release inside nucleus.

Preparation and Characterizations of RSPP050-Loaded Polymeric Micelles Using Poly(ethylene glycol)-<i>b</i>-Poly(ε-caprolactone) and Poly(ethylene glycol)-<i>b</i>-Poly(D,L-lactide)

“…The whole process was treated under 140°C. 13,25) Water Solubility Study Solubility of AG50 in water was detected by UV-Vis spectroscopy. First, 1 mg of AG50 was dissolved in 2.5 mL of THF.…”

“…The molecular weight of these copolymers can be varied which in turn controls the particle size, drug encapsulation, and drug release of the polymeric micelles. 13,14) Several methods for micelle preparations have been examined to encapsulate hydrophobic drug in polymeric micelles. Solvent evaporation method, film sonication, and dialysis method are widely used for micelle preparation.…”

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“…Other works has been conducted by Theerasilp and Nasongkla. 7 Parenteral microparticles of poly (DL-lactic-coglycolic acid) (PLGA) 50:50 and poly(ethylene glycol) (PEG) blends with entrapped model drug compounds to investigate the effect of blend ratio on release kinetics has been fabricated by Cleek et al, Two model drugs (FITC-IgG and FITCdextran) were entrapped using a double-emulsionsolvent-extraction technique with high efficiency.…”

Glucose-installed, SPIO-loaded PEG-b-PCL micelles as MR contrast agents to target prostate cancer cells

“…Micelles were prepared by solvent evaporation method (Theerasilp and Nasongkla 2013). Firstly, HOOC-PEG-b-PCL and SPIO were dissolved in THF and was added dropwise into DI water, while the mixture was sonicated continuously (SONIC, Model VCX 130).…”