COMPARATIVE STUDIES OF PATIENTS WITH TAKAYASU ARTERITIS IN JAPAN, KOREA AND INDIA : Comparison of Clinical Manifestations, Angiography and HLA-B Antigen

Childhood‐onset Takayasu arteritis: an update

“…North American patients with c-TA also tend to have aortic involvement similar to that seen in adult TA patients from the Asian Indian population. 6 A large series of 40 children with c-TA from our center in south India has reported a high proportion (78%) of sub-diaphragmatic aorta involvement.…”

Comparative study of the residues 63 and 67 on the HLA-B molecule in patients with Takayasu's Arteritis

“…Several Major Histocompatibility Complex (MHC) genes have been associated with the disease in diverse ethnic groups. For instance, patients from India, Korea, Thailand and Japan present a high frequency of HLA-B5201 allele, whereas other studies suggest that HLA-B39 allele and HLA-B52, DRB1*1501, DRB5*0102, DQA1*0103, DQB1*0601, DPA1*02, DPB1*0401 haplotype could be the genetics markers in Japanese population [6][7][8][9][10]. Interestingly in our study, we detected seven patients with B52 and/or B39 alleles, and the other patients presented the B15, B40 and B44 alleles.…”

“…Some Major Histocompatibility Complex (MHC) genes have been associated to the genetic susceptibility to develop Takayasu's Arteritis in several populations including the Mexican. HLA-B52 is associated with the disease in India, Thailand, Korea, Japan and Mexico; HLA-B39 allele and HLA-B52, DRB1*1501, DRB5*0102, DQA1*0103, DQB1*0601, DPA1*02, DPB1*0401 haplotype have been associated in the Japanese population [6][7][8][9][10][11]. More recent data note direct participation of the HLA-B alleles in the susceptibility to the disease.…”

Aortitis Syndrome (Takayasu's Arteritis). A Historical Perspective.

“…It was recently reported to be 6.6 (112:17) According to the comparative study of Takayasu's arteritis in 3 Asian countries by Yajima et al,22) lesions of the aortic arch and/or its branches were found angiographically in 99% of 96 Japanese, 83% of 109 Korean and 68% of 50 Indian patients, while lesions of the abdominal aortic area were found in 34%, 76% and 92%, respectively, indicating differences in the distribution of arterial involvement among the 3 groups. The frequency of aortic regurgitation was significantly higher in Japanese patients (33.3%) than in Korean (6.4%) and Indian patients (4.0%).…”