Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease
Abstract:In Alzheimer’s disease (AD) glial fibrillary acidic protein (GFAP) is expressed by reactive astrocytes surrounding β‐amyloid (Aβ) plaques, whereas brain‐derived neurotrophic factor (BDNF) levels are typically reduced. We compared the expression of GFAP, BDNF, and its precursor proBDNF in the dorsal hippocampus of two transgenic AD mouse models. APPSwe YAC mice expressing the APPSwe transgene on a yeast artificial chromosome (YAC) were assessed at age 4 and 21 months, and APPSwe/PS1dE9 mice co‐expressing mutant… Show more
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