Comparative Studies of Enteric Bacterial Flora in Acne Vulgaris1

Loveman, David E.; Noojin, Ray O.; Winkler, Charles H.

doi:10.1038/jid.1955.110

Cited by 13 publications

(7 citation statements)

References 2 publications

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“…The first attempt to determine if there were differences in the intestinal bacterial microflora was a 1955 investigation that focused on the presence or absence of potentially pathogenic bacteria in 10 acne patients vs. controls. Obviously there can be few generalizations drawn from a study involving only 10 subjects with acne, and the authors simply concluded that there appeared to be no major differences (vs. controls) in a small selection of enteric bacteria genera under culture technique [41]. However, we find it noteworthy that Bacteroides spp were more commonly isolated from the acne patients, particularly since elevations of Bacteroides have been noted in humans under psychological stress [42].…”

Section: Introductionmentioning

confidence: 68%

Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?

Bowe

Logan²

2011

Gut Pathog

209

146

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Over 70 years have passed since dermatologists John H. Stokes and Donald M. Pillsbury first proposed a gastrointestinal mechanism for the overlap between depression, anxiety and skin conditions such as acne. Stokes and Pillsbury hypothesized that emotional states might alter the normal intestinal microflora, increase intestinal permeability and contribute to systemic inflammation. Among the remedies advocated by Stokes and Pillsbury were Lactobacillus acidophilus cultures. Many aspects of this gut-brain-skin unifying theory have recently been validated. The ability of the gut microbiota and oral probiotics to influence systemic inflammation, oxidative stress, glycemic control, tissue lipid content and even mood itself, may have important implications in acne. The intestinal microflora may also provide a twist to the developing diet and acne research. Here we provide a historical perspective to the contemporary investigations and clinical implications of the gut-brain-skin connection in acne.

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Section: Introductionmentioning

confidence: 68%

Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?

Bowe

Logan²

2011

Gut Pathog

209

146

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“…The first attempt to examine the intestinal bacterial microflora took place in a 1955 investigation of 10 acne patients. While the small sample group does not allow for generalisations to be made, the authors did conclude there were no major differences in a small subset of potentially pathogenic bacteria in acne patients vs. controls using culture technique (Loveman et al, 1955). Interestingly, we find it note-worthy that Bacteroides spp.…”

Section: Intestinal Microfloramentioning

confidence: 61%

Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine

Bowe

Patel²,

Logan

2014

109

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Acne vulgaris has long been postulated to feature a gastrointestinal mechanism, dating back 80 years to dermatologists John H. Stokes and Donald M. Pillsbury. They hypothesised that emotional states (e.g. depression and anxiety) could alter normal intestinal microbiota, increase intestinal permeability, and contribute to systemic inflammation. They were also among the first to propose the use of probiotic Lactobacillus acidophilus cultures. In recent years, aspects of this gut-brain-skin theory have been further validated via modern scientific investigations. It is evident that gut microbes and oral probiotics could be linked to the skin, and particularly acne severity, by their ability to influence systemic inflammation, oxidative stress, glycaemic control, tissue lipid content, and even mood. This intricate relationship between gut microbiota and the skin may also be influenced by diet, a current area of intense scrutiny by those who study acne. Here we provide a historical background to the gut-brain-skin theory in acne, followed by a summary of contemporary investigations and clinical implications.

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“…As of yet, it is unknown whether the efficacy of oral antibiotics in the treatment of acne is due to systemic absorption and action directly within the acne lesion or indirectly by action upon the local intestinal microbiome 26 . In this study, we sought to better understand the gut and skin microbiota in acne patients and whether it is impacted by antibiotic treatment.…”

Section: Discussionmentioning

confidence: 99%

Minocycline and Its Impact on Microbial Dysbiosis in the Skin and Gastrointestinal Tract of Acne Patients

et al. 2020

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Background: Associations between acne and gastrointestinal comorbidities suggest that microbial dysbiosis and intestinal permeability may promote inflammatory acne, a condition often managed with oral antibiotics. Objective: We performed a case-control study to investigate the skin and gut microbiota in 8 acne patients before and after receiving oral minocycline compared to controls matched by age ±5 years, sex, and race. Methods: DNA was extracted from stool samples and facial skin swabs. Sequencing of the V3V4 region of the bacterial 16S rRNA gene was performed using Illumina MiSeq and analyzed using QIIME/MetaStats 2.0 software. Results: Acne patients included 7 female and 1 male, ages 20∼ 32. Shannon diversity was not significantly different between the skin (p=0.153) or gut (p<0.999) microbiota of acne patients before and after antibiotics. The gut microbiota in pre-antibiotic acne patients compared to acne-free controls was depleted in probiotics Lactobacillus iners (p=0.001), Lactobacillus zeae (p=0.001), and Bifidobacterium animalis (p=0.026). After antibiotics, the gut microbiota of acne patients was depleted in Lactobacillus salivar-ius (p=0.001), Bifidobacterium adolescentis (p=0.002), Bifidobacterium pseudolongum (p=0.010), and Bifidobacterium breve (p=0.042), while the skin microbiota was enriched in probiotics Bifidobacterium longum (p=0.028) and Leuconostoc mesenteroides (p=0.029) and depleted in Staphylococcus epidermidis (p=0.009) and Prevotella nigrescens (p=0.028). At the phylum level, significant enrichment of Bacteroidetes in stool of acne patients following antibiotic treatment (p=0.033) led to a decreased Firmicutes to Bacteroidetes ratio. Conclusion: Minocycline produces significant derangements in the microbiota of the skin and gut, including many probiotic species, highlighting the potential for more targeted antimicrobial treatments for acne. (Ann Dermatol 32(1) 21∼30, 2020

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Comparative Studies of Enteric Bacterial Flora in Acne Vulgaris1

Cited by 13 publications

References 2 publications

Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?

Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?

Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine

Minocycline and Its Impact on Microbial Dysbiosis in the Skin and Gastrointestinal Tract of Acne Patients

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