Comparative Sporicidal Effects of Disinfectants after Release of a Biological Agent

Kenar, Levent; Ortatatli, Mesut; Yaren, Hakan; Karayilanoglu, Turan; Aydoğan, Hakan

doi:10.7205/milmed.172.6.616

Cited by 15 publications

(12 citation statements)

References 15 publications

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“…Over the years many studies have focused on different bactericidal techniques for B. anthracis and their comparative effect on survival, including ultraviolet [44,48-50,214] and various chemicals [15,34,39,215]. Two of the ultraviolet studies were geared toward surrogate selection.…”

Section: Comparative Survivability Among Surrogatesmentioning

confidence: 99%

Identifying experimental surrogates for Bacillus anthracis spores: a review

Greenberg

Busch

Keim³

et al. 2010

Investig Genet

101

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Bacillus anthracis, the causative agent of anthrax, is a proven biological weapon. In order to study this threat, a number of experimental surrogates have been used over the past 70 years. However, not all surrogates are appropriate for B. anthracis, especially when investigating transport, fate and survival. Although B. atrophaeus has been widely used as a B. anthracis surrogate, the two species do not always behave identically in transport and survival models. Therefore, we devised a scheme to identify a more appropriate surrogate for B. anthracis. Our selection criteria included risk of use (pathogenicity), phylogenetic relationship, morphology and comparative survivability when challenged with biocides. Although our knowledge of certain parameters remains incomplete, especially with regards to comparisons of spore longevity under natural conditions, we found that B. thuringiensis provided the best overall fit as a non-pathogenic surrogate for B. anthracis. Thus, we suggest focusing on this surrogate in future experiments of spore fate and transport modelling.

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Section: Comparative Survivability Among Surrogatesmentioning

confidence: 99%

Identifying experimental surrogates for Bacillus anthracis spores: a review

Greenberg

Busch

Keim³

et al. 2010

Investig Genet

101

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“…Various kinds of technologies were compared for effective decontamination of Bacillus spores. 56,57) By BCWAs dissemination, the agents are incorporated into the surface materials with adsorption and deposition. The material contaminated by the agents is called "coupon," and exert the influence on the efficiency of the decontamination method.…”

Section: Concept Of Decontaminationmentioning

confidence: 99%

Research and Development of On-site Decontamination System for Biological and Chemical Warfare Agents

Seto

2011

JOURNAL OF HEALTH SCIENCE

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Biological and chemical warfare agents (BCWAs) are diverse in nature including synthetic low molecular weight chemical warfare agents (gaseous choking and blood agents), volatile nerve gases and blister agents, nonvolatile vomit agents and lachrymators, biological toxins (polar low molecular weight toxins and proteinous toxins), and microorganisms (viruses, rickettsia, chlamydia and bacteria). In the consequence management against chemical and biological warfare terrorism, speedy decontamination of casualties, goods, items and equipments, buildings and field is required for the minimization of the terrorism damage. At present, washing casualties and contaminated materials with large volumes of water is the basic way, and hypochlorite solution is mainly used to decompose BCWAs. However, it still remains unsolved how to dispose the waste water contaminated with BCWAs, and decontaminating reagents have serious problems of high toxicity to human, despoiling nature to environment, long finishing time and non-durability. In addition, the present decontamination technologies are not effective, nonspecifically affecting the surrounding non-target materials. Therefore, it is the urgent matter to build up usable decontamination system surpassing the present system. The author introduces the joint project of research and development of the novel decontamination system against BCWAs, in the purpose of realizing non-dangerous, rapid, specific, effective and economical on-site decontamination. The project consists of establishment of the evaluation methods for decontamination, and verification of the present technologies and utilization of bacterial organophosphorus hydrolase, development of specific adsorptive elimination technologies using molecular recognition devices, and development of deactivation technologies using photocatalysis.

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“…The use of other decontamination options, such as hypochlorite solution, may be effective at spore reduction but may cause damage to electronic equipment due to its corrosive nature [22]. It is for this reason that formaldehyde gas would be selected as the decontaminant of choice for electronic equipment, where recovery of data is the primary evidentiary concern.…”

Section: Resultsmentioning

confidence: 99%