Comparative skeletal mass and radial bone mineral content in black and white women

Cohn, S. H.; Abesamis, Concepcion; Yasumura, S; Aloia, John F.; Zanzi, I.; Ellis, Kenneth J.

doi:10.1016/0026-0495(77)90052-x

Cited by 209 publications

(43 citation statements)

References 18 publications

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“…Moreover, the decline in serum immunoreactive PTH varies in proportion to the amount of weight lost. In ongoing studies, we found that urinary cAMP is increased in obese white subjects and correlates with ideal body weight (63 (65). We found biochemical changes in normal black nonobese subjects similar to those described above in obese white individuals (67).…”

Section: Regulation Of Vitamin D Metabolismsupporting

confidence: 79%

Vitamin D-endocrine system.

Bell¹

1985

J. Clin. Invest.

142

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Section: Regulation Of Vitamin D Metabolismsupporting

confidence: 79%

Vitamin D-endocrine system.

Bell¹

1985

J. Clin. Invest.

142

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“…This we regard as unlikely, since a reduction in calcium absorption would eventually lead to a decrease instead of the well-documented increase in bone mass in blacks (1,2). Also, our finding of a reduction rather than an increase in mean serum Gla protein in the blacks, despite increases in circulating PTH, is evidence for altered skeletal response to the hormone.…”

Section: Resultsmentioning

confidence: 62%

“…Urinary calcium was consistently higher in the whites, and the increment in response to 1,25(OH)2D3 was greater in them. Mean serum phosphate increased significantly (Table III), and there was a transient increase on day 5 in urinary phosphate in response to 1,25(OH)2D3 in both groups (Table IV) (2). The explanation that increased strain on the skeleton modifies the response to PTH in blacks is open to question, in view of the fact that skeletal mass is greater in men than in women, and the fact that there were no differences in values for serum immunoreactive PTH and serum 1,25(OH)2D in the men and women in the present study.…”

Section: Resultsmentioning

confidence: 96%

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Evidence for alteration of the vitamin D-endocrine system in blacks.

Bell¹,

Greene²,

Epstein³

et al. 1985

J. Clin. Invest.

407

214

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As compared with values in white subjects, bone mass is known to be increased and urinary calcium to be diminished in black individuals. To evaluate the possibility that these changes are associated with alterations in the vitamin Dendocrine system, an investigation was performed in 12 black subjects, 7 men and 5 women, and 14 white subjects, 8 men and 6 women, ranging in age from 20 to 35 yr. All of them were hospitalized on a metabolic ward and were given a constant daily diet containing 400 mg of calcium, 900 mg of phosphorus, and 110 meq of sodium. Whereas mean serum calcium, ionized calcium, and phosphate were the same in the two groups, mean serum immunoreactive parathyroid hormone (350±34 vs. 225±26 pg/ml, P < 0.01) and mean serum 1,25-dihydroxyvitamin D (1,25(OH)2D) (41±3 vs. 29±2 pg/ml, P < 0.01) were significantly higher, and mean serum 25-hydroxyvitamin D (25-OHD) was significantly lower in the blacks than in the whites (6±1 vs. 20±2 ng/ml, P < 0.001). Mean urinary sodium and 24-h creatinine clearance were the same in the two groups, whereas mean urinary calcium was significantly lower (101±14 vs. 166±13 mg/d, P < 0.01) and mean urinary cyclic AMP was significantly higher (3.11±0.47 vs. 1.84±0.25 nM/dl glomerular filtrate, P < 0.01) in the blacks. Further, the blacks excreted an intravenous calcium load, 15 mg/kg body weight, as efficiently as the whites (49±3 vs. 53±3%, NS). Mean serum Gla protein was lower in blacks than in whites (14±2 vs. 24±3 ng/ml, P < 0.02), and increased significantly in both groups in response to 1,25(OH)2D3, 4

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“…Regular weight-bearing exercise stimulates osteoblast function, and increases bone density (53,54). Muscle mass and bone mass, in fact, are directly related (55).…”

Section: General Introductionmentioning

confidence: 99%

Age, gender and diet effects on gene expression regulated by 1,25-dihydroxyvitamin D3

Johnson

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This manuscript has been reproduced from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer.The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction.In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book.

show abstract

Comparative skeletal mass and radial bone mineral content in black and white women

Cited by 209 publications

References 18 publications

Vitamin D-endocrine system.

Vitamin D-endocrine system.

Evidence for alteration of the vitamin D-endocrine system in blacks.

Age, gender and diet effects on gene expression regulated by 1,25-dihydroxyvitamin D3

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