Comparative Significance of p53 and WAF/l-p2 1 Expression on the Efficacy of Adjuvant Chemotherapy for Resectable Invasive Ductal Carcinoma of the Pancreas

Expression of Gadd45a and p53 proteins in human pancreatic cancer: Potential effects on clinical outcomes

“…Yamasawa reported firstly that Gadd45a expression had correlation to the differentiation of pancreatic cancer and that detection of Gadd45a mutation in pancreatic cancer. On the contrary to our result, their further analysis found that in the p53(þ) patients, Gadd45a(þ) patients showed prognosis apparently shorter than that of Gadd45a(À) patients, which indicates the co-expression of p53 and Gadd45a may affect the patients' prognosis [3].…”

“…Gadd45a protein is widely distributed in cells of normal tissues; however, the significance of its overexpression in tumor cells is not clear. It is reported that over 50% of pancreatic cancer can occur p53 mutation and thereof protein overexpression [3], while Gadd45a overexpression accounts for 54.2% in human pancreatic cancer [4]. The fact above indicates the participation of these two genes into the occurrence and development of pancreatic cancer.…”

Expression of Bcl‐2 and p53 protein in resectable invasive ductal carcinoma of the pancreas: Effects on clinical outcome and efficacy of adjuvant chemotherapy

“…However, p53 expression showed a signi®cant in¯uence on the ef®cacy of ACT, and for patients with p53( ) IDC, survival of the ACT group was signi®cantly better than that of the SA group (P 0.024). We had reported the same results [39], and the present study including the additional patients con®rm the previous results. By contrast, ACT did not improve the survival in either the pBcl-2( ) group or in the pBcl-2( À ) group.…”

“…Recent reports suggest that p53 gene has a dual role as a trigger of apoptosis and as an initiator of DNA repair, suggesting that p53 gene has a signi®cant effect on the ef®cacy of chemotherapy [40]. We also reported that adjuvant chemotherapy (ACT) signi®cantly improved the survival after pancreatectomy in the patients with p53( ) IDC [39], although another report indicated no association between p53 expression and the ef®cacy of chemotherapy or radiotherapy [41]. Accordingly, we have to con®rm our previous results by accumulating the additional patients with IDC.…”

p53 alteration is not an independent prognostic indicator, but affects the efficacy of adjuvant chemotherapy in human pancreatic cancer

“…Another study, however, showed that p53 alterations increased the sensitivity of tumor cells to ACT in bladder cancer [24]. Expression of p53 protein was also noted to affect the efficacy of ACT in invasive ductal carcinoma (IDC) of the pancreas and was associated with a shorter or longer survival for pancreatic cancer patients who received ACT [25][26][27][28].…”