Comparative Sensitivity of Specific Amino Acid Ratios versus “Essential to Nonessential” Amino Acid Ratio

Arroyave, Guillermo

doi:10.1093/ajcn/23.6.703

Cited by 51 publications

(27 citation statements)

References 2 publications

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“…Our previous work showed that the protein sparing action of energy intake had more effect than the protein intake itself on N utilization in men with a submaintenance intake of N (unpublished data by WOVE et al 4). SINGH et al (28) observed increased levels of plasma EAAs in marasmic children and similar findings were obtained by SALEM et al (6) in protein-energy-deficient rats.…”

Section: Discussionmentioning

confidence: 57%

“…WHITEHEAD (2) found a characteristic change in 297 the pattern of plasma-free amino acids in infants with PEM and proposed a "nonessential to essential amino acid ratio" as a criterion for diagnosis of this condition. Abnormal amino acid ratios have also been observed by others in human infants (3,4) and adults (5) and in rats (6). There is also evidence that plasma-free amino acids are influenced by not only protein deficiency but also energy intake and other factors.…”

mentioning

confidence: 56%

“…This implies that an N intake sufficient to maintain a zero balance may not be sufficient to maintain hematological values at physiologically normal levels. 4 …”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of low-protein diets on free amino acids in plasma of young men: Effect of protein quality with maintenance or excess energy intake.

Fujita

Yoshimura

Inoue

1978

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Section: Discussionmentioning

confidence: 57%

mentioning

confidence: 56%

See 1 more Smart Citation

Effect of low-protein diets on free amino acids in plasma of young men: Effect of protein quality with maintenance or excess energy intake.

Fujita

Yoshimura

Inoue

1978

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Plasma amino acids in anorexia nervosa D Moyano et al content of the intake) (Oberholzer et al, 1990), Gly/Val (index of protein malnutrition) (Arroyave, 1970), Met/Cys (indicator of sulfur metabolism) (Roediger, 1995;Ghisol® et al, 1978).…”

Section: Expression Of Resultsmentioning

confidence: 99%

Plasma amino acids in anorexia nervosa

Moyano¹,

Vilaseca²,

Artuch³

et al. 1998

Eur J Clin Nutr

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Objective: To evaluate the amino acid pro®le in a group of adolescents with anorexia nervosa, and to apply alternative ways of presenting and assessing results, so as to increase the information available for understanding the metabolic abnormalities developed in these patients. Design: Plasma amino acid concentrations of a random group of patients with anorexia nervosa compared with values obtained from a`healthy' adolescent population. Setting: The study was performed at the tertiary children's Hospital Sant Joan de De Âu. Subjects: Female adolescents (n 92, age: 15 AE 1.8 y) at diagnosis of anorexia nervosa. Reference values for amino acids were obtained from apparently healthy adolescents (by history and analytical data) who underwent presurgical analysis for minor operations. Interventions: Plasma amino acid concentrations were measured by ion exchange chromatography. Basic laboratory analysis, carnitine and IGF-I were also determined. Results: In anorexic patients plasma concentrations of taurine, asparagine, glutamine, glycine, methionine, phenylalanine, ornithine, and histidine were signi®cantly higher than reference values (Mann-Whitney, P`0.01±0.0001), whereas arginine and cystine were lower than our reference values (P`0.0001). Relative amino acid values (the molar fraction of the patient medians relative to control medians) were plotted. The ratios of some amino acids were signi®cantly greater than those obtained from the reference population: Phe/Tyr (P`0.001), Met/Cys (P`0.0001), and Gly/Val (P`0.01). Conclusions: A trend to hyperaminoacidemia is a common feature in anorexia nervosa. Although absolute amino acid values cannot play a signi®cant role in the assessment of nutritional status in this condition, the calculation of some ratios (Phe/Tyr, Met/Cys and Gly/Val) and the graphical representation of relative values may be useful. The plasma amino acid pro®le in anorexia nervosa is different from those of other severe malnutrition states, showing a marasmic pattern of balanced protein±energy undernutrition. Cystine and arginine may be considered limiting amino acids in this disease, and the consequences of their de®cient concentrations for oxidative damage should be further evaluated.

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“…Dean and Whitehead (1963) were the first to suggest that the ratio of valine/glycine in plasma provided a valid index of protein nutrition. More recent studies by Arroyave (1970) confirmed that several amino acid ratios, in partic ular that of valine/glycine, were altered in malnourished newborn infants, as well as in children and adults suffering protein deprivation. Lindblad and Zetterstrom (1971) studied plasma amino acid metabolism in a group of eight infants of low birth weight born to mothers with toxaemia of pregnancy.…”

Section: Introductionmentioning

confidence: 91%

Valine/Glycine Ratio in Newborn Infants

Hibbard¹,

Kenna²

1975

Neonatology

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The ratio of valine/glycine was measured in the umbilical cord blood of 213 newborn infants of singleton pregnancies. The results obtained in small-for-date and preterm infants are compared with those in normal-term infants. A parallel assessment was made of the valine/glycine ratio in venous blood of the mothers of all these infants. An abnormally high rate was found in a small number of infants and also in a few mothers. There did not appear to be any association between these abnormal results and intra-uterine growth retardation.

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Comparative Sensitivity of Specific Amino Acid Ratios versus “Essential to Nonessential” Amino Acid Ratio

Cited by 51 publications

References 2 publications

Effect of low-protein diets on free amino acids in plasma of young men: Effect of protein quality with maintenance or excess energy intake.

Effect of low-protein diets on free amino acids in plasma of young men: Effect of protein quality with maintenance or excess energy intake.

Plasma amino acids in anorexia nervosa

Valine/Glycine Ratio in Newborn Infants

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