Comparative safety of teicoplanin and vancomycin

Wilson, A.P.R.

doi:10.1016/s0924-8579(98)00025-9

Cited by 90 publications

(52 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was reported that patients with a serum trough concentration >60 µg/mL had a higher incidence of elevated serum creatinine levels than those with concentrations of 20-40 µg/ mL (p<0.05). 14) Presterl et al 15) showed a moderate increase in liver enzymes during teicoplanin treatment. In this study, nephrotoxicity and hepatotoxicity were each observed in only one of 20 adult patients.…”

Section: Discussionmentioning

confidence: 99%

Development of Initial Loading Procedure for Teicoplanin in Critically Ill Patients with Severe Infections

Matsumoto

Kanazawa

Watanabe

et al. 2013

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Methicillin-resistant Staphylococcus aureus (MRSA) is now endemic in many hospitals. Infection with MRSA is more frequent in the intensive care unit (ICU) than in general wards. Therefore, appropriate treatments for MRSA infections will lead to good outcomes in the ICU. Teicoplanin is an anti-MRSA agent. Recently, it was recommended at a new target trough concentration of 15-30 µg/mL. However, the initial loading procedure for teicoplanin to allow it to reach the target concentration promptly remains uncertain. Therefore, this study aimed to determine the appropriate initial loading procedure for teicoplanin in critically ill patients with severe infections. We performed a retrospective study in patients given teicoplanin in the ICU in order to determine the initial loading procedure to promptly reach the target trough concentration. We then evaluated the trough concentration on the third day after commencement of teicoplanin therapy. The mean loading dose and trough concentration were 11.5±1.0 mg/kg and 18.9±5.9 µg/mL, respectively. A correlation (r=0.45, p=0.046) was shown between teicoplanin loading dose and trough concentration. The correlation equation was trough concentration=2.563·loading dose −10.672. In the cases of 11.0 and 15.0 mg/ kg for the loading dose, respectively, trough concentrations were 17.5 and 27.8 µg/mL. We suggested that an initial loading dose of 11-15 mg/kg every 12 h for 3 doses should be administered to promptly achieve the target trough concentration of 15-30 µg/mL on the third day after commencement of teicoplanin therapy in the ICU.

show abstract

Section: Discussionmentioning

confidence: 99%

Development of Initial Loading Procedure for Teicoplanin in Critically Ill Patients with Severe Infections

Matsumoto

Kanazawa

Watanabe

et al. 2013

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…This is because of the need for additional blood samples and healthcare personnel, and the associated increase in treatment costs. 4,9,23 Teicoplanin was well tolerated in the newborn with acute renal failure even when given in excessive dosage. 24 Teicoplanin, similar to vancomycin, does not cause severe hepatic toxicity in adult patients.…”

Section: Discussionmentioning

confidence: 99%

“…The results of comparative trials in the USA revealed that teicoplanin nephrotoxicity in adult patients is similar to that of vancomycin (6.2% and 6.5%, respectively), although it was less common with teicoplanin, especially when an aminoglycoside was added. 4,9 In large, non-comparative trials of teicoplanin in adult patients, the incidence of increased creatinine levels has varied from 0.3% to 0.8%. 9 Degraeuwe et al 5 did not find evidence of teicoplanin nephrotoxicity, including serum creatinine and alterations in creatinine clearance, in pre-term neonates.…”

Section: Discussionmentioning

confidence: 99%

“…4,9 In large, non-comparative trials of teicoplanin in adult patients, the incidence of increased creatinine levels has varied from 0.3% to 0.8%. 9 Degraeuwe et al 5 did not find evidence of teicoplanin nephrotoxicity, including serum creatinine and alterations in creatinine clearance, in pre-term neonates. None of our patients showed any signs of nephrotoxicity based on BUN, creatinine concentration and calculated GFR before and after treatment.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Experience with Teicoplanin in the Treatment of Neonatal Staphylococcal Sepsis

et al. 2004

View full text Add to dashboard Cite

We aimed to evaluate retrospectively the clinical and bacteriological efficacy and potential side-effects of teicoplanin treatment in neonates with proven staphylococcal infection. There were 37 episodes of staphylococcal septicaemia in neonates with a mean gestational age of 34.2 ± 2.3 weeks; 26 were caused by coagulasenegative staphylococcal (CoNS) sepsis and 11 by Staphylococcus aureus sepsis. All episodes were treated with teicoplanin (intravenous loading dose 16 mg/kg followed by a maintenance dose of 8 mg/kg daily). The methicillin resistance and antibiotic susceptibilities of both micro-organisms were evaluated. Bacterial eradication was achieved in 89.1% of cases and mortality was 16.2%. The mean duration of treatment of the survivors was 11.6 ± 2.3 days. There were no drug-related adverse events and the biochemical and haematological tests showed no clinically significant changes in relation to teicoplanin therapy. Our results suggest that teicoplanin is highly effective in neonatal staphylococcal sepsis.

show abstract

“…RMS occurs due to histamine release from mast cells and basophils located in the skin, lung, gastrointestinal tract, myocardium, and vascular system 8 . Antibiotics such as ciprofloxacin, amphotericin B, rifampicin and teicoplanin can potentially cause red man syndrome 9 . Red man syndrome is aggravated in patients receiving vancomycin with opioid analgesics or muscle relaxants 4 .…”

Section: Case Reportmentioning

confidence: 99%

Red man syndrome: an unusual complication of vancomycin beads

Juyal

Khurana

Maheshwari

2015

Bangladesh J Med Sci

View full text Add to dashboard Cite

Abstract:Vancomycin is a bactericidal antibiotic. It is commonly used to treat Methicillin Resistant Staphylococcus Aureus (MRSA) infections. It is also used locally with Polymethyl methacrylate to treat chronic bone infections. Locally placed beads deliver high concentration of antibiotics locally with few adverse effects as compared to parenteral therapy. There are two complications mentioned on intravenous infusion of vancomycin namely anaphylactic reaction and red man syndrome; but there is no known literature on complications arising from vancomycin impregnated cement beads. We report a case of red man syndrome following usage of vancomycin impregnated cement beads which is not reported in any available orthopaedic literature.

show abstract

Comparative safety of teicoplanin and vancomycin

Cited by 90 publications

References 81 publications

Development of Initial Loading Procedure for Teicoplanin in Critically Ill Patients with Severe Infections

Development of Initial Loading Procedure for Teicoplanin in Critically Ill Patients with Severe Infections

Experience with Teicoplanin in the Treatment of Neonatal Staphylococcal Sepsis

Red man syndrome: an unusual complication of vancomycin beads

Contact Info

Product

Resources

About