Comparative routes of oxytocin administration in crated farrowing sows and its effects on fetal and postnatal asphyxia

Mota-Rojas, Daniel; Ortega, María Elena Trujillo; Martínez, J.M. Arroyo; Rosales, Ana M.; Orozco, Héctor; Ramírez, Roberto Morales; López, Héctor Sumano; Alonso-Spilsbury, M.

doi:10.1016/j.anireprosci.2005.04.012

Cited by 40 publications

(30 citation statements)

References 12 publications

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“…Given the previous experience using the tococardiograph in obstetrics for sows (Mota‐Rojas et al. , 2006), in this study we propose using the equation used in human medical practice to calculate Montevideo Units, and applied them to veterinary medicine, with the intent to evaluate uterine activity in sows during the farrowing process.…”

Section: Discussionmentioning

confidence: 99%

“…, 2005), causes greater fetal mortality (Alonso‐Spilsbury et al. , 2004; Mota‐Rojas et al. , 2006), and diminishes vitality (Mota‐Rojas et al.…”

Section: Introductionmentioning

confidence: 99%

“…The uterotonic drugs frequently used to diminish mortality at birth effectively reduce the length of the piglet birth process (Straw et al, 2000;Mota-Rojas et al, 2005a,c). However, at times it increases the intensity and frequency of contractions in the uterus, which in turn damages the UC (Linneen et al, 2005), causes greater fetal mortality (Alonso-Spilsbury et al, 2004;Mota-Rojas et al, 2006), and diminishes vitality (Mota-Rojas et al, 2007a). Any increase in the tension of the UC during the birth process causes circulatory alterations in the UC; this increases the risk of anoxia at the time of birth and leads to a high rate of perinatal death (Randall, 1972).…”

Section: Introductionmentioning

confidence: 99%

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Uterine activity and fetal electronic monitoring in parturient sows treated with vetrabutin chlorhydrate

González-Lozano

Ortega

Becerril-Herrera

et al. 2010

Journal of Veterinary Pharmacology and Therapeutics

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The aims of the study were to characterize the uterine activity in sows treated with vetrabutin chlorhydrate (VC), an uterotonic and muscle-tropic drug during farrowing, and to measure the effects of the drug on piglet neonatal viability. The experiment involved 1478 piglets from 130 Yorkshire-Landrace sows, randomly allotted into two groups. Farrowing monitoring began 12 h after PGF2alpha synchronization. Group 1 was given physiological solution (G1, n = 65); Group 2 was treated with VC (1 mL/60 kg LW) at the initiation of fetal expulsion (G2, n = 65). In spite of the total duration of expulsion being significantly longer (P < 0.0001), approximately 35 min in the VC treatment, VC application at the time the first piglet was expulsed favored the alive birth of at least one more piglet. Even though the pressure in the uterus was similar in both groups, the number and duration of uterus contractions recorded were significantly less (P < 0.0001) in G2, favoring fewer births with acute fetal suffering, compared with that in G1. VC treated group compared with the control group also had fewer (5.01% vs. 24%) alterations in umbilical cords, as well as a lesser incidence of secondary apnea (2.08% vs. 7.46%) and bradycardia (1.94% vs. 7.61%), which favored a significantly higher vitality score (P < 0.002). With the intent to evaluate uterine activity in sows during the farrowing process, we propose using the equation used in human medical practices to calculate Montevideo Units applied to swine obstetrics for the first time.

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Section: Discussionmentioning

confidence: 99%

“…, 2005), causes greater fetal mortality (Alonso‐Spilsbury et al. , 2004; Mota‐Rojas et al. , 2006), and diminishes vitality (Mota‐Rojas et al.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Uterine activity and fetal electronic monitoring in parturient sows treated with vetrabutin chlorhydrate

González-Lozano

Ortega

Becerril-Herrera

et al. 2010

Journal of Veterinary Pharmacology and Therapeutics

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show abstract

“…This might suggest that the intervention procedure around farrowing is not optimal in the experimental herd. Indeed, Mota-Rojas et al (2006) showed that contractions that are induced with injection of oxytocin decrease uterine blood flow and increase fetal acidosis during farrowing, with an effect of dosage and time for administration. Similarly, it seems that the use of birth assistance is controversial: it may have detrimental (Cassar et al, 2005), neutral (Kaeoket (2006) or beneficial (Balogh and Bilkei, 2003) effects on farrowing survival.…”

Section: Within-breed Structurementioning

confidence: 98%

Comparison of sow farrowing characteristics between a Chinese breed and three French breeds

et al. 2009

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“…No entanto, no experimento II, não houve diferença na natimortalidade entre os tratamentos (Tabela 2). Segundo MOTA-ROJAS et al (2006), a administração de ocitocina no início do trabalho de parto, mesmo em doses recomendadas, representa uma situação de risco para o aumento da natimortalidade, resultando em contrações prolongadas da musculatura uterina, produzindo contratilidade rítmica no útero, que causa pressão sobre o cordão umbilical e diminui o fluxo sanguíneo e a quantidade de oxigênio para os leitões. Como consequência, ocorre morte por asfixia, uma das causas mais importantes da mortalidade de leitões, classificada como morte intra-parto.…”

Section: Resultsunclassified

Indução de partos em suínos: uso de cloprostenol associado com ocitocina ou carbetocina

et al. 2011

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O presente estudo teve como objetivo avaliar o efeito da aplicação de um análogo sintético da PGF2 (cloprostenol sodico), associado à ocitocina ou carbetocina, sobre a eficiência da indução ao parto em suínos. O experimento I foi realizado com 284 fêmeas, distribuídas em quatro tratamentos: cloprostenol; cloprostenol e 0,100mg de carbetocina; cloprostenol e 10UI de ocitocina; solução salina (NaCl 0,9%). No experimento II, foram utilizadas 276 fêmeas, distribuídas em quatro tratamentos: cloprostenol; cloprostenol e 0,10mg de carbetocina; cloprostenol e 0,05mg de carbetocina; cloprostenol e 10UI de ocitocina. A indução do parto foi realizada aos 113 dias de gestação, pela aplicação de 0,175mg de cloprostenol, via submucosa vulvar. A carbetocina ou a ocitocina foram aplicadas 24h após a aplicação de cloprostenol, pela via intramuscular. O intervalo indução-parto foi menor (P<0,05) nos grupos cujo parto foi induzido com cloprostenol, em comparação ao grupo sem indução do parto. A aplicação de carbetocina ou ocitocina resultou em maior concentração dos partos (P<0,05) até 26 e 28h após a administração de cloprostenol. A utilização de carbetocina resultou em menor (P<0,05) duração do parto. No experimento I, o uso de ocitocina ou de carbetocina resultou em maior natimortalidade (P<0,05) do que no grupo sem indução do parto. Além disso, a natimortalidade foi maior (P<0,05) com o uso de carbetocina do que na indução somente com cloprostenol. No experimento II, não houve diferença na natimortalidade (P>0,05) entre os tratamentos. A utilização de ocitócitos, em associação com cloprostenol, resulta em partos antecipados e mais sincronizados. O uso associado de cloprostenol e carbetocina reduz o tempo de parto e 99% ou mais dos partos ocorrem em até quatro horas após a aplicação de carbetocina, independentemente da dose utilizada.

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Comparative routes of oxytocin administration in crated farrowing sows and its effects on fetal and postnatal asphyxia

Cited by 40 publications

References 12 publications

Uterine activity and fetal electronic monitoring in parturient sows treated with vetrabutin chlorhydrate

Uterine activity and fetal electronic monitoring in parturient sows treated with vetrabutin chlorhydrate

Comparison of sow farrowing characteristics between a Chinese breed and three French breeds

Indução de partos em suínos: uso de cloprostenol associado com ocitocina ou carbetocina

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