2015
DOI: 10.1001/jama.2015.15572
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Comparative Risk of Anaphylactic Reactions Associated With Intravenous Iron Products

Abstract: Among patients in the US Medicare nondialysis population with first exposure to IV iron, the risk of anaphylaxis was highest for iron dextran and lowest for iron sucrose.

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Cited by 183 publications
(178 citation statements)
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“…A 3 times higher rate of adverse events was found for iron dextran compared to other IV iron. Also, more anaphylactic reactions were seen after the first administration of IV iron compared to repeated administration [23]. This phenomenon is in line with our results and the description of CARPA [24].…”
Section: Discussionsupporting
confidence: 91%
“…A 3 times higher rate of adverse events was found for iron dextran compared to other IV iron. Also, more anaphylactic reactions were seen after the first administration of IV iron compared to repeated administration [23]. This phenomenon is in line with our results and the description of CARPA [24].…”
Section: Discussionsupporting
confidence: 91%
“…8 A very recent cohort of 688,183 new users of IV iron found anaphylaxis risk for nondextran products to be as low as 24 events/100,000 persons. 40 The true anaphylaxis rate might have been even lower because the positive predictive value of the algorithm used to identify anaphylaxis was only 63%. 40 Furthermore, newer IV iron formulations enable restoration of iron stores quickly and efficiently and are much more convenient for administration compared with older preparations.…”
Section: Discussionmentioning
confidence: 99%
“…Despite a relatively high prevalence of anemia, relatively few patients with stages 4-5 CKD are treated with intravenous (IV) iron, 10 owing to associated risks including anaphylactoid reactions, concerns regarding the need for multiple venous cannulations in patients who may require creation of arteriovenous fistula for hemodialysis, and a variety of logistic hurdles. 11,12 Ferric citrate functions as an intestinal phosphate binder, and has been approved by the US Food and Drug Administration and other major regulatory agencies for the treatment of hyperphosphatemia in patients on dialysis. 13,14 Prior studies in patients receiving dialysis and a phase 2 study in patients with NDD-CKD found ferric citrate to increase transferrin saturation, serum ferritin, and hemoglobin.…”
mentioning
confidence: 99%