Comparative risk of acute myocardial infarction for anti-osteoporosis drugs in primary care: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database

Khalid, Sara; Calderón-Larrañaga, Sara; Sami, A; Hawley, Samuel; Judge, Andrew; Arden, N K; Staa, T P van; Cooper, Cyrus; Abrahamsen, Bo; Javaid, Muhammad Kassim; Prieto‐Alhambra, Daniel

doi:10.1007/s00198-021-06262-1

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…However, the application of these drugs in clinical use is limited by their adverse side effects. Adverse effects that have been mentioned include subtrochanteric femoral fractures [ 4 ], osteonecrosis of the long bones and jaws [ 5 ], breast carcinoma, endometrial cancer, thromboembolic events, and cardiovascular disease [ 6 ]. Therefore, natural sources with fewer side effects but significant curative effects have attracted extensive attention.…”

Section: Introductionmentioning

confidence: 99%

Aloe polysaccharide promotes osteogenesis potential of adipose-derived stromal cells via BMP-2/Smads and prevents ovariectomized-induced osteoporosis

et al. 2022

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Background Aloe polysaccharide (AP) is a type of an active macromolecule of Aloe vera, which contributes to its function. However, whether AP possesses anti-osteoporosis properties is unknown. Methods Adipose-derived stromal cells were treated with different concentrations of AP. Early and late osteogenesis were, respectively, evaluated by ALP and Alizarin Red S staining. The effect of AP on the processes of adipogenesis inhibition in ADSCs was analyzed by oil red O staining. Western blot was used to assess the expression of osteogenic and adipogenic related factors. Then, Noggin was administered to further confirm the mechanism by which AP promotes the osteogenesis of ADSCs. Finally, 40 female SD rats were classified into a bilateral laparotomy group (Sham group) and three bilateral ovariectomy groups: OVX group, OVX + AP group, and OVX + AP + Noggin group. The bilateral rat femurs were collected to perform micro-CT scanning, HE, Masson trichrome, and Oil red O staining. Results The results indicated that AP could increase ALP expression and calcium deposition. Through molecular mechanisms, AP promotes the protein expression of COL1A1, OPN, and ALP in ADSCs, but downregulates the expression of PPARγ. Also, AP directs ADSCs’ fate by stimulating the BMP2/Smads signaling pathway. In vivo, the rat AP-treated had more trabecular bone than the OVX rat, indicating partial protection from cancellous bone loss after treatment with AP. Conclusion Our results show that AP may promote osteogenesis of ADSCs through BMP-2/Smads signaling pathway and inhibits lipogenic differentiation. Thus, AP might be a promising alternative medicine to treat postmenopausal osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Aloe polysaccharide promotes osteogenesis potential of adipose-derived stromal cells via BMP-2/Smads and prevents ovariectomized-induced osteoporosis

et al. 2022

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Side effects of drugs for metabolic bone disease

Walker,

Feiner,

North

et al. 2023

Side Effects of Drugs Annual

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The Role of Sympathetic Nerves in Osteoporosis: A Narrative Review

Zhang

Liu

et al. 2022

Biomedicines

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Osteoporosis, a systemic bone disease, is characterized by decreased bone density due to various reasons, destructed bone microstructure, and increased bone fragility. The incidence of osteoporosis is very high among the elderly, and patients with osteoporosis are prone to suffer from spine fractures and hip fractures, which cause great harm to patients. Meanwhile, osteoporosis is mainly treated with anti-osteoporosis drugs that have side effects. Therefore, the development of new treatment modalities has a significant clinical impact. Sympathetic nerves play an important role in various physiological activities and the regulation of osteoporosis as well. Therefore, the role of sympathetic nerves in osteoporosis was reviewed, aiming to provide information for future targeting of sympathetic nerves in osteoporosis.

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Comparative risk of acute myocardial infarction for anti-osteoporosis drugs in primary care: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database

Abstract: Please refer to any applicable terms of use of the publisher.

Cited by 3 publications

References 37 publications

Aloe polysaccharide promotes osteogenesis potential of adipose-derived stromal cells via BMP-2/Smads and prevents ovariectomized-induced osteoporosis

Aloe polysaccharide promotes osteogenesis potential of adipose-derived stromal cells via BMP-2/Smads and prevents ovariectomized-induced osteoporosis

Side effects of drugs for metabolic bone disease

The Role of Sympathetic Nerves in Osteoporosis: A Narrative Review

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