Comparative responsiveness to natural and synthetic estrogens of fish species commonly used in the laboratory and field monitoring

Lange, Anke; Katsu, Yoshinao; Miyagawa, Shinichi; Ogino, Yukiko; Urushitani, Hiroshi; Kobayashi, Tohru; Hirai, Toshiaki; Shears, Janice A.; Nagae, Masaki; Yamamoto, Jun; Ohnishi, Yuta; Oka, Tomohiro; Tatarazako, Norihisa; Ohta, Yasuhiko; Tyler, Charles R.; Iguchi, Taisen

doi:10.1016/j.aquatox.2011.09.004

Cited by 90 publications

(87 citation statements)

References 60 publications

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“…Even if a weakly estrogenic pesticide such as o, p'-DDT is present during the critical period of gonadal development of O. latipes, it can also profoundly alter sex (Edmunds et al, 2000). Lange et al (2012) reported that E3 may play an important role in the feminization process in roach. Holbech et al (2006) investigated water exposure of juvenile zebrafish to E3 for 40 days and found that the sex ratio was significantly altered towards females from 22 μg/L E3.…”

Section: Discussionmentioning

confidence: 99%

“…It was found that higher concentrations of E3 (1.62-9.55 nM) were necessary for the transcription of fish ERα compared to the induction by E2 (0.18-0.36 nM). Several studies have determined the estrogenic effects of E3 using in vitro assays (Tollefsen et al, 2003;Denny et al, 2005;Luo et al, 2011;Lange et al, 2012). However, few studies reported the estrogenic effect of E3 on fish using in vivo assays, and in these studies, only early life stage of fish was exposed to E3, or only single test endpoint such as intersex (i.e., testis-ova) in fish was investigated (Metcalfe et al, 2001;Holbech et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…They are a potent subset of steroid hormones and play important roles in the reproductive biology of vertebrates like fish (Lange et al, 2012). Steroidal estrogens exist widely in the aquatic environment originating mainly from domestic sewage, and the effluents from wastewater treatment plants and agriculture (Lei et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…For example, Luo et al (2011) utilized two-hybrid yeast bioassay to determine the relative potencies (RPs) of estrogens and found that the RPs of E3 and E1 relative to E2 were 0.0049 and 0.053, respectively. Lange et al (2012) used in vitro ERα activation assays for a range of fish species to determine estrogenic potencies. It was found that higher concentrations of E3 (1.62-9.55 nM) were necessary for the transcription of fish ERα compared to the induction by E2 (0.18-0.36 nM).…”

Section: Introductionmentioning

confidence: 99%

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Long-term exposure investigating the estrogenic potency of estriol in Japanese medaka (Oryzias latipes)

Lei

Kang

et al. 2014

Comparative Biochemistry and Physiology Part C: Toxicology &

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The growth, development, and ERα and Vtg-I gene expressions of Japanese ricefish (Oryzias latipes; medaka) exposed to different concentrations of estriol (E3), including one environmentally relevant concentration, during embryo-adult life stages were evaluated. At the early life stage, fertilized eggs were exposed to 5, 50, 500, 5000 ng/L E3 for 15 days, and the hatched fry were exposed continuously to the same concentrations for an additional 15 days. Exposure to 500 and 5000 ng/L E3 resulted in adverse effects on hatchability and time to hatching. At 5000 ng/L, the gross abnormality rate was increased and the number of females that hatched was twice that of males. When the fish were exposed to 5-5000 ng/L E3 for further 60 days, the male hepatosomatic index (HSI) was increased at 5000 ng/L. The female gonadosomatic index (GSI) was decreased at 500 and 5000 ng/L E3, while the male GSI at 5000 ng/L E3 was increased and sex reversal was also found at this concentration. Quantitative RT-PCR showed that the hepatic vitellogenin-I (Vtg-I) genes were up-regulated in females at 500 and 5000 ng/L E3 and in males at all E3 concentrations, whereas E3 did not affect estrogen receptor α (ERα) mRNA transcription. These results showed that E3 at environmental concentration of 5 ng/L has no adverse effects on growth and development of the Japanese medaka. However, in this study, if we only focused on Vtg gene change in males, E3 had strong estrogenic effects on male medaka under the conditions of these experiments.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long-term exposure investigating the estrogenic potency of estriol in Japanese medaka (Oryzias latipes)

Lei

Kang

et al. 2014

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…Both natural hormones (E1 and E2) and synthetic hormones (EE2) have endocrine disrupting effects such as reduced fertility and feminization of male fish (Tyler and Jobling, 2008;Bhandari et al, 2014;Iwanowicz et al, 2016). Exposure of male fish to estrogens can result in a range of effects from the complete sex reversal in most severe cases to different degrees of feminization including intersex and decreased expressions of secondary sex characteristics (Tabata et al, 2001;Gross-Sorokin et al, 2004;Lange et al, 2008;Länge et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Pollution by endocrine disrupting estrogens in aquatic ecosystems in Morogoro urban and peri-urban areas in Tanzania

Msigala¹,

Mabiki²,

Styrishave³

et al. 2017

Afr. J. Environ. Sci. Technol.

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This study aimed to assess the extent of pollution of aquatic ecosystems by endocrine disrupting estrogens particularly the ethinylestradiol (EE2), estrone (E2) and estradiol (E1). The study was carried out in Morogoro urban and peri-urban areas. The main sources of fresh water for domestic uses, fishing and agricultural activities in the study areas including the Mindu dam catchment area, Ngerengere and Morogoro Rivers were assessed. The endocrine disrupting estrogens in water samples were identified and quantified using competitive Enzyme Linked Immunosorbent Assay (ELISA) kits. The recovery of estrogens in this study ranged from 65 to 90.22%, the range which is within the acceptable level. The levels of estrogens in Ngerengere River ranged from non-detectable levels to 0.68, 0.03 to 8.42 and 0.05 to 16.97 ng/L for EE2, E2 and E1, respectively. At Mindu Dam the levels ranged from 0.07 to 0.3 ng/L, 0.41 to 2.1 ng/L and 2.6 to 6.5 ng/L for EE2, E2 and E1 respectively. Furthermore, for Morogoro River the levels ranged from undetected to 0.92, 0.34 to 9.53 and 0.17 to 11.49 ng/L for EE2, E2 and E1 respectively. Mean concentrations in control samples and those in upstream and midstream of the rivers were comparable (p > 0.05). But the mean concentrations in downstream portions were significantly higher than those in control samples (p < 0.05). These concentrations however, were below those reported in other studies to cause harmful health effects. Hence, the extent of pollution was not significant enough to cause adverse health effects to aquatic organisms and human.

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Toxicology

Bury¹

2015

Freshwater Fisheries Ecology

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Comparative responsiveness to natural and synthetic estrogens of fish species commonly used in the laboratory and field monitoring

Cited by 90 publications

References 60 publications

Long-term exposure investigating the estrogenic potency of estriol in Japanese medaka (Oryzias latipes)

Long-term exposure investigating the estrogenic potency of estriol in Japanese medaka (Oryzias latipes)

Pollution by endocrine disrupting estrogens in aquatic ecosystems in Morogoro urban and peri-urban areas in Tanzania

Toxicology

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