Comparative relationship between serum gastrin concentration and gastric acid output

Lanciault, G.; Merritt, A. M.; Rosato, Ernest F.; Bonoma, C.; Brooks, Frank P.

doi:10.1007/bf02231208

Cited by 7 publications

(1 citation statement)

References 6 publications

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“…The mean basal portal venous gastrin concentrations were about one-half those reported previously for miniature swine (Lanciault, Merritt, Rosato, Bonoma & Brooks, 1972). This difference is probably due to difference in immunoassay techniques rather than differences between groups ofpigs.…”

Section: Serum Gastrin and Secretion Concentrationmentioning

confidence: 50%

Simultaneous Pancreatic, Gastric and Hormonal Responses to 2‐deoxyglucose in the Conscious Pig

Merritt

Kolts

1983

Exp Physiol

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SUMMARYThe effect of vagal stimulation induced by 2-deoxy-D-glucose (2DG) on gastric acid and pancreatic bicarbonate output, and portal gastrin and secretin concentrations, was assessed in conscious miniature pigs. Electrical vagal stimulation has previously been shown to induce profuse pancreatic water and bicarbonate secretion in anaesthetized pigs. Pigs in this study were surgically prepared with gastric and pancreatic fistulas and indwelling jugular and portal catheters. An intravenous bolus of 2DG (100 mg/kg body weight) caused a significant increase in both gastric acid and pancreatic bicarbonate output although the latter was about 50% of the reported response to electrical vagal stimulation. Portal gastrin concentration rose significantly after 2DG, but the portal secretin concentration did not change. The presence of secretin in the small intestine was confirmed by intrajejunal HCI infusion. Failure of portal secretin concentration to rise after 2DG infusion rules against a role for this hormone in the pancreatic response.

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Section: Serum Gastrin and Secretion Concentrationmentioning

confidence: 50%