Comparative randomised trial of high and conventional doses of praziquantel in the treatment of schistosomiasis mansoni

Sensitivity and specificity of the circulating cathodic antigen rapid urine test in the diagnosis of Schistosomiasis mansoni infection and evaluation of morbidity in a low- endemic area in Brazil

“…All patients with S. mansoni infection received a single oral dose of praziquantel given by a physician (50mg/kg of body weight) 16 .…”

Thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for Schistosomiasis mansoni

“…A 10-ml sample of blood was collected from a peripheral vein in a tube containing ethylenediamine tetraacetic acid (EDTA) as an anticoagulant, and a hemogram with platelet counts was performed (Sysmex, E 2100 D). Individuals positive for schistosomiasis were treated with a single oral dose of praziquantel (50mg/kg body weight) 27 .…”

Neurologic manifestations of the neglected tropical diseases

“…Although cases of schistosomiasis-associated CNS vasculitis and pelvic floor myopathy have been described, a causal relationship was not definitively confirmed [101][102][103][104]. Although randomized trials have demonstrated the benefits of praziquantel for nonneurologic manifestations of schistosomiasis such as intestinal or urinary tract involvement [105][106][107][108][109], the management of neuroschistosomiasis is described only in case series [110][111][112]. For the treatment of CNS involvement, experts recommend praziquantel with concurrent corticosteroids, both to treat neuro-inflammatory sequalae of schistosomiasis, and since anti-parasitic treatment can induce a hypersensitivity reaction with features including headache, hemiparesis, seizure, encephalopathy and cerebellar signs [99].…”