Comparative quantitative structure–activity study of radical scavengers

Vajragupta, Opa; Boonchoong, Preecha; Wongkrajang, Yuvadee

doi:10.1016/s0968-0896(00)00195-4

Cited by 50 publications

(30 citation statements)

References 19 publications

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“…Para tener una mejor claridad sobre la capacidad que tiene un antioxidante para inhibir radicales libres, esta parte del trabajo se realizó utilizando el Software de Sistema de Modelamiento Molecular -HyperChem (Vérsion 6,01) (STATSOFT, 2000), determinando el Análisis Conformacional de Mínima Energía, reportado por Van Acker et al (1996);Vajragupta, Boonchoong, Wongkrajang (2000) y Webb et al (2000).…”

Section: C) Poder Antirradicalunclassified

Antocianinas, ácido ascórbico, polifenoles totales y actividad antioxidante, en la cáscara de camu-camu (Myrciaria dubia (H.B.K) McVaugh)

Villanueva-Tiburcio¹,

Condezo-Hoyos²,

Asquieri³

2010

Ciênc. Tecnol. Aliment.

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Section: C) Poder Antirradicalunclassified

Antocianinas, ácido ascórbico, polifenoles totales y actividad antioxidante, en la cáscara de camu-camu (Myrciaria dubia (H.B.K) McVaugh)

Villanueva-Tiburcio¹,

Condezo-Hoyos²,

Asquieri³

2010

Ciênc. Tecnol. Aliment.

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“…More recently quantitative structure activity relationship (QSAR) studies have served as an efficient tool to elucidate the structure-activity relationships of antioxidants (Jing et al, 2012;Vajragupta, Boonchoong, & Wongkrajang, 2000;Yamagami, Akamatsu, Motohashi, Hamada, & Tanahashi, 2005). This study aimed to build the QSAR models of the anthocyanins using the comparative molecular field analysis (CoMFA) and the comparative molecular similarity indices analysis (CoMSIA) methods to predict eggplant/radish anthocyanins potential with high oxygen radical absorbance capacity and also understand their quantitative structure-activity relationships.…”

Section: Introductionmentioning

confidence: 99%

Quantitative studies on structure–ORAC relationships of anthocyanins from eggplant and radish using 3D-QSAR

et al. 2014

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“…Health disorders such as diabetes mellitus, hypertension, cancer, neurodegenerative, gastric ulcers, reperfusion, arthritis and infammatory diseases are linked to the unchecked activities of ROS (Halliwell 1989;Vajragupta et al 2000). Antioxidants are well known to scavenge free radicals and ROS, and interrupting the radical chain reaction of lipid peroxidation, thereby preventing oxidative damage (Halliwell 1999).…”

Section: Introductionmentioning

confidence: 99%

Characterization of the antioxidant properties of phenolic extracts from some citrus peels

2011

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This study sought to determine the distribution of free and bound phenolics in some Nigerian citrus peels [orange (Citrus sinensis), grapefruit (Citrus paradisii) and shaddock (Citrus maxima)] and characterize the antioxidant properties. The free phenolics were extracted with 80% acetone, while the bound phenolics were extracted from the alkaline and acid hydrolyzed residue with ethyl acetate. Free phenolic extracts had significantly higher (P < 0.05) DPPH* scavenging ability than the bound phenolic extracts, except in orange peels where the bound phenolic extracts had significantly higher (P<0.05) DPPH* scavenging ability. Bound phenolics from orange peels had the highest ABTS* scavenging ability (6.09 mmol./TEAC g) and ferric reducing antioxidant properties (FRAP) (71.99 mg/GAE 100 g), while bound phenolics from shaddock peels had the least ABTS* scavenging ability (1.35 mmol./TEAC g) and FRAP (2.58 mg/GAE 100 g) . Bound phenolics from grapefruit peels had the highest OH* scavenging ability (EC 50 = 3.8 mg/ml), while bound phenolics from shaddock peels had the least (EC 50 =16.1 mg/ml). The phenolics chelated Fe 2+ and inhibited malondialdehyde production in rat's pancreas in a dose-dependent manner. The additive and/or synergistic action of the free and bound phenolics could have contributed to the observed medicinal properties of the peels; therefore, the high antioxidant properties of the free and bound phenolic extracts from orange peels could be harness in the formulation of nutraceuticals and food preservatives.

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Comparative quantitative structure–activity study of radical scavengers

Cited by 50 publications

References 19 publications

Antocianinas, ácido ascórbico, polifenoles totales y actividad antioxidante, en la cáscara de camu-camu (Myrciaria dubia (H.B.K) McVaugh)

Antocianinas, ácido ascórbico, polifenoles totales y actividad antioxidante, en la cáscara de camu-camu (Myrciaria dubia (H.B.K) McVaugh)

Quantitative studies on structure–ORAC relationships of anthocyanins from eggplant and radish using 3D-QSAR

Characterization of the antioxidant properties of phenolic extracts from some citrus peels

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