Comparative pulmonary toxicity study of nano-TiO2 particles of different sizes and agglomerations in rats: Different short- and long-term post-instillation results

Kobayashi, Norihiro; Naya, Masato; Endoh, Shigehisa; Maru, Junko; Yamamoto, Kazuhiro; Nakanishi, Junko

doi:10.1016/j.tox.2009.08.002

Cited by 144 publications

(112 citation statements)

References 19 publications

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“…Therefore, both the particle aggregate size and the primary size should be considered in evaluating size-dependent toxicity. However, the size-dependent effects were not confirmed in vivo in groups of rats dosed with different agglomerations of TNPs of equal primary size [110].…”

Section: Aggregate Sizementioning

confidence: 88%

“…ROS-mediated membrane breakdown and metabolic pathway alterations induced by TNPs were size-dependent [94]. In a pulmonary toxicity evaluation of instilled TNPs of different primary sizes, the smaller particles were found to induce more severe inflammation in the short term [110]. In lungs, the likelihood that NPs would escape alveolar macrophage phagocytosis was highly and inversely related to size.…”

Section: Primary Sizementioning

confidence: 98%

“…Size is widely considered a primary factor in nanotoxicity [39,[107][108][109][110]. Exposure to NPs was reported to induce greater inflammation than exposure to larger particles with identical chemical composition and mass concentration [30,[111][112][113][114][115].…”

Section: Primary Sizementioning

confidence: 99%

“…In the absence of special modifications, TNPs would be expected to aggregate in body fluids, according to dynamic light scattering results [31]. For example, the average diameter of Degussa P25 measured by dynamic light scattering was 542 nm in de-ionized water and 3500 nm in DMEM, while its primary size was approximatly 26 nm [110]. There is no discernable relationship between agglomeration size, primary size, and crystalline structure.…”

Section: Aggregate Sizementioning

confidence: 99%

See 3 more Smart Citations

The potential health risk of titania nanoparticles

Zhang

Bai

Zhang

et al. 2012

Journal of Hazardous Materials

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Section: Aggregate Sizementioning

confidence: 88%

Section: Primary Sizementioning

confidence: 98%

Section: Primary Sizementioning

confidence: 99%

Section: Aggregate Sizementioning

confidence: 99%

See 2 more Smart Citations

The potential health risk of titania nanoparticles

Zhang

Bai

Zhang

et al. 2012

Journal of Hazardous Materials

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“…On the other hand, with regard to the inflammatory effect of TiO 2 nanoparticles, Warheit et al 16) reported that their intratracheal instillation study showed only transient inflammation in lung tissue. Kobayashi et al 17,18) also carried out an intratracheal instillation study of anatase TiO 2 particles with different primary diameter and agglomeration states (size of agglomeration) in rats and compared the effects of particles on the lung. As a result, exposure to TiO 2 particles showed transient inflammation at a dose of 5 mg/kg that disappeared from 1 wk to 1 month after the instil- lation; the recovery from inflammation was nearly the same irrespective of the primary diameter and agglomeration states of TiO 2 particles.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Gene Expression of MMP-2 and TIMP-2 mRNA in Rat Lung in Inhaled Nickel Oxide and Titanium Dioxide Nanoparticles

et al. 2011

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In order to investigate whether or not dispersed nanoparticles have an effect of inflammation and fibrosis on animals, we developed a nanoparticle generation system and examined the gene expression of matrix metalloproteinase (MMP) and tissue inhibitor matrix proteinase (TIMP) in rat lung containing inhaled nickel oxide (NiO) or titanium dioxide (TiO 2 ) nanoparticles. In both experiments, Wistar male rats were exposed to NiO or TiO 2 nanoparticles for 4 wk (6 h/day). The geometric mean diameters of NiO and TiO 2 in the chamber were 139 ± 12 nm and 51 ± 9 nm, respectively. The average concentration of the particle number of NiO and TiO 2 was 1.0E+05 /cm 3 and 2.8E+05 /cm 3 , respectively. At 4 d, 1 and 3 months after the end of the inhalation, the rats exposed to these particles were sacrificed and the gene expressions of MMP-2, TIMP-2 and type I collagen were measured using RT-PCR. Pathological finding revealed that there was minimum inflammation with nickel oxide only at 4 d and no change with titanium oxide. However, there were no changes of the gene expression of MMP-2, TIMP-2, and type I collagen in either the NiO or TiO 2 exposure groups. In this study, inhalation of nickel oxide and titanium dioxide nanoparticles did not induce the gene expression of MMP-2 and TIMP-2 mRNA in rat lungs.

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Health Effects of Nanoparticles

Baeza‐Squiban

Boland

Hussain

et al. 2009

General, Applied and Systems Toxicology

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Increasing utilizations of nanomaterials in the industrial as well as consumer products augment the possibilities of environmental and occupational human exposures. Because of this fact, nanoparticles (NPs) have become potential candidates for the risk assessment. Among the possible exposure routes, inhalation represents the most important route of non‐intentional exposure to NPs. There are increasing evidences that NPs exhibit ability to cross biological barriers getting access to the bloodstream and secondary target organs where they could accumulate and induce pathological consequences. The surface area and reactivity of particles increase many fold relative to particle mass as particle size is reduced. Together with chemical composition, they constitute important determinants of NPs toxicity. They contribute in the production of reactive oxygen species (ROS) leading to the toxicological outcomes induced by NPs. In this study, we present a systemic overview of the current knowledge on the exposure, secondary organ translocation and potential health effects of the NPs. Moreover, potential mechanisms of NP‐induced cellular effects and role of physico‐chemical characteristics are elaborated. The potentially deleterious effects of NPs require further studies in order to build on our mechanistic understanding of the toxicological events in which they can be implicated.

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Comparative pulmonary toxicity study of nano-TiO2 particles of different sizes and agglomerations in rats: Different short- and long-term post-instillation results

Cited by 144 publications

References 19 publications

The potential health risk of titania nanoparticles

The potential health risk of titania nanoparticles

Investigation of Gene Expression of MMP-2 and TIMP-2 mRNA in Rat Lung in Inhaled Nickel Oxide and Titanium Dioxide Nanoparticles

Health Effects of Nanoparticles

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