Comparative Proteomic Study of Proteins in Prostate Cancer and Benign Hyperplasia Cells

Шишкин, С. С.; Kovaleva, M. A.; Ivanov, Alexei V.

doi:10.4172/1948-5956.s1-003

Cited by 2 publications

(4 citation statements)

References 31 publications

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“…Using proteomic technologies (two-dimensional electrophoresis (2-DE) and mass-spectrometric identification) the authors revealed that Cfl-1 was involved in processes of cell differentiation in colorectal adenocarcinoma (Caco-2) cell line. Later, Cfl-1 was identified in different tumor cell lines and tissues including adenocarcinomas [ 15 , 140 , 141 , 142 , 143 ], osteosarcoma [ 144 ], lymphoid tissue neoplasms [ 145 ], astrocytoma [ 146 ], glioma [ 147 ], and neuroblastoma [ 148 ]. Accordingly, it is possible to think that Cfl-1 is a common participant in various tumor phenotypes.…”

Section: Members Of the Actin-depolymerizing Factor/cofilin Superfmentioning

confidence: 99%

“…The accumulated data suggests that changes in cell motility can be triggered by certain actin-binding proteins (ABPs) which provide the formation, function, and restructuring of the actin cytoskeleton [ 10 , 11 , 12 , 13 ]. The detection of these changes allows the clarification of the molecular basis of malignant transformation and the role of certain proteins (in particular, ABPs) in this process [ 11 , 12 , 13 ], and, in addition, allows the list of potential tumor biomarkers to expand [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Over the past ten years coflin-1 (Cfl-1) has attracted special attention among ABPs [ 14 , 16 , 17 ], along with other members of the actin-depolymerizing factor (ADF)/cofilin superfamily [ 18 , 19 ]. In particular, in our previous studies of the proteomic profiles of different human malignant cells (HMCs), Cfl-1 was almost always found as one of the major proteins [ 15 ], and that fact is reflected in the Russian proteomic databases [ 20 , 21 ]. As a consequence, it is interesting to analyze some current trends in the study of ADF/cofilin superfamily members.…”

Section: Introductionmentioning

confidence: 99%

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Cofilin-1 and Other ADF/Cofilin Superfamily Members in Human Malignant Cells

Shishkin

Eremina

Pashintseva

et al. 2016

IJMS

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Identification of actin-depolymerizing factor homology (ADF-H) domains in the structures of several related proteins led first to the formation of the ADF/cofilin family, which then expanded to the ADF/cofilin superfamily. This superfamily includes the well-studied cofilin-1 (Cfl-1) and about a dozen different human proteins that interact directly or indirectly with the actin cytoskeleton, provide its remodeling, and alter cell motility. According to some data, Cfl-1 is contained in various human malignant cells (HMCs) and is involved in the formation of malignant properties, including invasiveness, metastatic potential, and resistance to chemotherapeutic drugs. The presence of other ADF/cofilin superfamily proteins in HMCs and their involvement in the regulation of cell motility were discovered with the use of various OMICS technologies. In our review, we discuss the results of the study of Cfl-1 and other ADF/cofilin superfamily proteins, which may be of interest for solving different problems of molecular oncology, as well as for the prospects of further investigations of these proteins in HMCs.

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Section: Members Of the Actin-depolymerizing Factor/cofilin Superfmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cofilin-1 and Other ADF/Cofilin Superfamily Members in Human Malignant Cells

Shishkin

Eremina

Pashintseva

et al. 2016

IJMS

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“…It is believed that such molecules could be potential biomarkers and/or targets for chemotherapy. The use of malignant cell lines and technologies of modern biochemistry is an effective basis for searching for key molecules ex vivo [77][78][79][80][81][82] . Ex vivo culture systems in experimental oncology are also used for study of potential anticancer drugs.…”

Section: Human Malignant Cells and Post-genomic Technologies In Expermentioning

confidence: 99%

Modern Biochemistry in Research of Human Malignant Cells and Experimental Oncology

Шишкин

2016

Journal of Biochemistry and Molecular Biology Research

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characteristics and the gene expression patterns. Thus, the use of malignant cell lines ex vivo (as models of human cancers) is an important trend in search for key molecules of carcinogenesis in experimental oncology. EDITORIALThe biochemistry has a place of honor among the life sciences largely due to its fantastic success in 20 th century. Traditional biochemistry started with the study of chemical components of living organisms and their metabolism that provides life itself, and with description of the main types of biopolymers and other biomolecules. At that time technologies allowing to determine sequence of monomers in complex polymers such as nucleic acids and proteins (sequencing technologies) were designed. As a result, in the 80s of the 20 th century the entire human mitochondrial genome was identified, heavy and light mitochondrial DNA strands maps were constructed and their nucleotide sequences were determined [1,2] . Further similar studies were concerned with the complete genome sequencing of different bacteria and some eukaryotes [3][4][5] . In the last decade of 20 th century the DNA sequencing of the human nuclear genome was started that influenced the development of the life sciences [6][7][8] . To achieve the goal of determining the DNA sequence of the entire human genome the considerable resources of the international ABSTRACTModern biochemistry or biochemistry of 21th century is developing in many traditional fields: investigations of proteins, nucleic acids, lipids, carbohydrates, metabolites and metabolic processes, etc, however it has gained new features that based on success of Human Genome Project and on application of high performance technologies (post-genomic technologies). As a result, at the turn of the 21st century some new scientific disciplines, named "OMICS" (proteomics, transcriptomics, lipidomics, glycomics, metabolomics, etc) were created through advances in the biochemistry. Currently "OMICS" and post-genomic technologies are involved in mainstream of cancer research, including studies of human malignant cells. Since malignant tumors consist of heterogeneous cancer cells, the cultured cell lines have some advantages over biopsy simples for studies aimed at understanding the molecular basis of carcinogenesis. The malignant human cell lines differ considerably in their origin from tissues or organs, and therefore they vary widely in the differentiation EDITORIAL

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Comparative Proteomic Study of Proteins in Prostate Cancer and Benign Hyperplasia Cells

Cited by 2 publications

References 31 publications

Cofilin-1 and Other ADF/Cofilin Superfamily Members in Human Malignant Cells

Cofilin-1 and Other ADF/Cofilin Superfamily Members in Human Malignant Cells

Modern Biochemistry in Research of Human Malignant Cells and Experimental Oncology

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