Comparative Potency of Pipecuronium Bromide and Pancuronium Bromide

Abstract

Cumulative dose-response curves were constructed to determine the comparative potency of pipecuronium and pancuronium. From these, the ED50 and ED95 values were calculated. These were 24.96 micrograms kg-1 and 44.96 micrograms kg-1, respectively, for pipecuronium and 30.42 micrograms kg-1 and 61.12 micrograms kg-1, respectively, for pancuronium.

Effect of isoflurane and sevoflurane on the magnitude and time course of neuromuscular block produced by vecuronium, pancuronium and atracurium

“…The M M G-based potency estimates, assessed in the current study with an opioid-nitrous oxideoxygen anaesthetic, were consistent with previously determined values for vecuronium [18,19], pan curonium [20] and atracurium [18,19] using the cumulative dose technique.…”

Design, synthesis and evaluation of novel 16-imidazolyl substituted steroidal derivatives possessing potent diversified pharmacological properties

“…It has also been observed from our previous studies that a variation in the interonium distance, although increased, resulting from the built in flexibility about the single bond on the moieties linked to ring D of a bisquaternary steroid is not desirable for favourable NMJ blocking effects [19]. Pipecuronium bromide with an interonium distance of 16.07 Å produces less cardiovascular side effects in comparison to pancuronium bromide (11.00 [20,21], however an increase in onset of action was observed. A value of about 10-14 Å is considered as optimal interonium distance for skeletal muscle relaxant effects.…”

The Effect of Pancuronium Bromide as a Muscle Relaxant Alone or Combination With Diazepam in Sheep

“…More than Use pancuronium bromide alone. At the same time the neuromuscular action of pancuronium may be reversed by the administration of atropine sulphate (15,16).…”