Comparative potency and pharmacology of isomers of leukotriene D4 on guinea-pig trachea: Requirement for a 5(S)6(R) configuration

Tsai, Bie Shung; Bernstein, Peter R; Macia, R.A.; Conaty, J.; Krell, Robert D.

doi:10.1016/0090-6980(82)90111-3

Cited by 18 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contractions were monitored by means of a Grass (FT.03C) force displacement transducer and recorded on a Beckman R-511A recorder. Synthetic LTD4 was used as a standard (Tsai et al, 1982). SRS-A is expressed as nanogram equivalents of LTD4 released per gram wet weight lung.…”

Section: Introduction Methodsmentioning

confidence: 99%

Differential effect of cyclo‐oxygenase inhibition on antigen‐ and ionophore‐induced release of slow reacting substance from fragmented guinea‐pig lung

Krell

Kusner

1984

British J Pharmacology

View full text Add to dashboard Cite

The nonsteroidal anti‐inflammatory drugs (NSAID) indomethacin and mefenamic acid, at concentrations ranging from 3 μM to 18 μM, enhanced antigen‐induced slow reacting substance of anaphylaxis (SRS‐A) release from sensitized fragmented guinea‐pig lung. In contrast, these agents had no effect on SRS‐A release from nonsensitized guinea‐pig lung induced by several concentrations of the calcium ionophore, A23187. Neither increasing preincubation time with the NSAID nor the use of sensitized tissue resulted in an enhancement of A23187‐induced SRS‐A release by indomethacin. NSAID did not alter histamine release by either stimulus. These results suggest that antigen and A23187 induce SRS‐A release from different sources or by different mechanisms in guinea‐pig lung.

show abstract

Section: Introduction Methodsmentioning

confidence: 99%

Differential effect of cyclo‐oxygenase inhibition on antigen‐ and ionophore‐induced release of slow reacting substance from fragmented guinea‐pig lung

Krell

Kusner

1984

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…Pulmonary function parameters were recorded at 2-or 5-min intervals and included breathing fre quency (0. pulmonary resistance (RL), peak expiratory flow rate (PEFR), tidal volume (VT) and dynamic compliance (Cdyn). These were recorded and ascaris aerosol challenges were done using pre viously described techniques [11,12], Leukotrienes LTD., was prepared as described previously [13]. The LTD., was analyzed spectrophotometrically at 280 nm before and after the aerosol experiments.…”

Section: Pulmonary Function Studiesmentioning

confidence: 99%

Airway Response to Leukotriene D<sub>4</sub> in Rhesus Monkeys

Patterson

Harris

Smith

et al. 1983

Int Arch Allergy Immunol

View full text Add to dashboard Cite

We studied the effect of leukotriene D₄ (LTD₄) given by aerosol challenge on asthmatic and normal monkeys. The response to LTD₄ occurred within 2 min., was prolonged at higher concentrations, was reversed by epinephrine, and more closely resembled an antigen response than a histamine response. Since LTD₄ concentrations of 30–100 μg/ml produced a response similar to 2–20 mg/ml of histamine, the LTD₄ was 300–900 times as potent as histamine on a molar basis. Thus, LTD₄, which appears to reproduce an antigen-induced response in rhesus monkeys, may be a mediator of allergic asthma in these animals.

show abstract

The Development of Cysteinyl Leukotriene Receptor Antagonists

Bernstein

2012

Analogue‐Based Drug Discovery III

View full text Add to dashboard Cite

Comparative potency and pharmacology of isomers of leukotriene D4 on guinea-pig trachea: Requirement for a 5(S)6(R) configuration

Cited by 18 publications

References 19 publications

Differential effect of cyclo‐oxygenase inhibition on antigen‐ and ionophore‐induced release of slow reacting substance from fragmented guinea‐pig lung

Differential effect of cyclo‐oxygenase inhibition on antigen‐ and ionophore‐induced release of slow reacting substance from fragmented guinea‐pig lung

Airway Response to Leukotriene D<sub>4</sub> in Rhesus Monkeys

The Development of Cysteinyl Leukotriene Receptor Antagonists

Contact Info

Product

Resources

About