Comparative polyphenolic profiling of five ethnomedicinal plants and their applicative potential in the treatment of type 2 diabetes

Kukavica, Biljana; Škondrić, Siniša; Trifković, Tanja; Mišić, Danijela; Gašić, Uroš; Topalić-Trivunović, Ljiljana; Savić, Aleksandar; Velemir, Ana; Davidović-Plavšić, Biljana; Šešić, Milica; Lukić, Nataša

doi:10.1016/j.jep.2023.117377

Cited by 1 publication

(1 citation statement)

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“…Thus, reduction of ROS has been proposed as an effective strategy for mitigating inflammation and complications associated with diabetes ( Cheng et al, 2019 ). Several natural antioxidants including polyphenols, have been shown to reduce the risk of T2DM via increasing the antioxidant defense, regulating inflammatory response and decreasing blood glucose and insulin resistance ( Shah et al, 2022 ; Kukavica et al, 2024 ). Therefore, it is in need to further discover high-efficiency, low-toxicity and multi-target antioxidants for diabetes and its complications.…”

Section: Discussionmentioning

confidence: 99%

N-p-coumaroyloctopamine ameliorates hepatic glucose metabolism and oxidative stress involved in a PI3K/AKT/GSK3β pathway

Huang,

Zhang,

et al. 2024

Front. Pharmacol.

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Type 2 diabetes mellitus is regarded as a chronic metabolic disease characterized by hyperglycemia. Long-term hyperglycemia may result in oxidative stress, damage pancreatic β-cell function and induce insulin resistance. Herein we explored the anti-hypoglycemic effects and mechanisms of action of N-p-coumaroyloctopamine (N-p-CO) in vitro and in vivo. N-p-CO exhibited high antioxidant activity, as indicated by the increased activity of SOD, GSH and GSH-Px in HL-7702 cells induced by both high glucose (HG) and palmitic acid (PA). N-p-CO treatment significantly augmented glucose uptake and glycogen synthesis in HG/PA-treated HL-7702 cells. Moreover, administration of N-p-CO in diabetic mice induced by both high-fat diet (HFD) and streptozotocin (STZ) not only significantly increased the antioxidant levels of GSH-PX, SOD and GSH, but also dramatically alleviated hyperglycemia and hepatic glucose metabolism in a dose-dependent manner. More importantly, N-p-CO upregulated the expressions of PI3K, AKT and GSK3β proteins in both HG/PA-induced HL-7702 cells and HFD/STZ-induced mice. These findings clearly suggest that N-p-CO exerts anti-hypoglycemic and anti-oxidant effects, most probably via the regulation of a PI3K/AKT/GSK3β signaling pathway. Thus, N-p-CO may have high potentials as a new candidate for the prevention and treatment of diabetes.

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Section: Discussionmentioning

confidence: 99%