Comparative plasma lipid response of pullets and laying hens to estradiol and progesterone

Hagan, R.C.; Leszczynski, D. E.; Kummerow, Fred A.

doi:10.1016/0041-008x(84)90352-1

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…The simplest interpretation is that Kpf is a measure of relative lipid content of plasma and fat [21]. The concentration of total lipoprotein lipid in plasma of nonlaying birds is approximately 0.005 g/ml [22] which is very similar to the mean partition coefficient from the present study (Ta-ble 1). Therefore, the concentration of total lipids in plasma is probably a reasonably good approximation of Kpf for many OCs.…”

Section: Plasma/fut Partition Coefficientsupporting

confidence: 80%

Dynamics of organochlorine compounds in herring gulls (Larus argentatus): II. A two‐compartment model and data for ten compounds

Clark¹,

Norstrom²,

Fox³

et al. 1987

Enviro Toxic and Chemistry

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A two‐compartment open model using plasma and seasonally variable lipid compartments was developed and validated for several organochlorines in herring gulls (Larus argentatus). Plasma clearance rate constants (k′pc, L·kg−1·d−1), plasma: whole‐body lipid partition coefficients (Kpf) and compartment sizes for lipid and plasma were obtained for juvenile gulls injected i.p. with a mixture of p,p′‐DDD, p,p′‐DDE, hexachlorobenzene, oxychlordane, γ‐hexachlorocyclohexane, trans‐chlordane, octachlorostyrene, dieldrin, mirex and photomirex. Concentrations in plasma were determined at 11 time points during the 239‐d study, and whole‐body contaminant burdens and lipid weights were determined at 3 time points. Mean Kpf for p,p′‐DDD and p,p′‐DDE (0.0038 ± 0.0002) was different from that of the other organochlorines (0.0058 ± 0.0005, n = 7). The latter values were close to the expected fraction lipid in plasma, indicating a simple thermodynamic partitioning between lipid pools in adipose tissue and plasma. Plasma clearance rate constants ranged from approximately 0.04 L·kg−1·d−1 for slowly clearing organochlorines such as p,p′‐DDE and mirex to 500 L·kg−1·d−1 for rapidly clearing γ‐hexachlorocyclohexane and trans‐chlordane. Simulations using these parameters and lipid weight regimes for individual experimental birds tracked observed plasma concentrations and final body burdens closely. Simulated whole‐body half‐lives of organochlorines in wild adult gulls were similar to those published for other species.

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Section: Plasma/fut Partition Coefficientsupporting

confidence: 80%

Dynamics of organochlorine compounds in herring gulls (Larus argentatus): II. A two‐compartment model and data for ten compounds

Clark¹,

Norstrom²,

Fox³

et al. 1987

Enviro Toxic and Chemistry

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“…Oestradiol concentrations were measured using a double-antibody radioimmunoassay (RIA) (Webb et al, 1985). This followed an initial purification similar to that described by Peterson and Common (1972) and Hagan et al (1984), except that toluene was substituted for benzene, to remove the large amount of lipid present in laying hen plasma.…”

Section: Oestradiol Assaymentioning

confidence: 99%

Regulation of plasma oestrogen by dietary fats in the laying hen: Relationships with egg weight

Whitehead

Bowman

Griffin

1993

British Poultry Science

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1. Feeding a diet supplemented with maize oil was found to elevate plasma oestradiol concentration in laying hens. 2. In a larger-scale experiment, isoenergetic and isonitrogenous diets containing 10, 20, 40 or 60 g/kg supplemental maize oil, tallow, coconut oil or fish oil were fed for 5 weeks. 3. Egg weights showed very different responses to the different fats. The responses could be described by quadratic functions that all gave optimum responses with supplemental dietary fat concentrations of about 40 g/kg. Egg weight increased the most with maize oil and was decreased with fish oil at the highest inclusion rate. 4. Measurements of egg components showed a relatively larger increase in albumen weights with maize oil than with other fats. 5. Across treatments, mean plasma oestradiol concentrations were very highly correlated (r = 0.96) with the changes in egg weights over the experimental period. 6. It is concluded that oestrogen is important in controlling egg weight and that the effect of dietary fats in influencing egg weight is mediated by an effect of the fats on oestrogen metabolism.

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“… D Redshaw and Follett (1976) . E Neill et al (1977) ; Hagan et al (1984) ; Lien et al (2001) ; Peebles et al (2004) ; and Lv et al (2018) . F Neill et al (1977) and Hagan et al (1984) .…”

Section: Resultsmentioning

confidence: 99%

“… E Neill et al (1977) ; Hagan et al (1984) ; Lien et al (2001) ; Peebles et al (2004) ; and Lv et al (2018) . …”

Section: Resultsmentioning

confidence: 99%

Quantitative Morphometric, Physiological, and Metabolic Characteristics of Chickens and Mallards for Physiologically Based Kinetic Model Development

et al. 2022

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Physiologically based kinetic (PBK) models are a promising tool for xenobiotic environmental risk assessment that could reduce animal testing by predicting in vivo exposure. PBK models for birds could further our understanding of species-specific sensitivities to xenobiotics, but would require species-specific parameterization. To this end, we summarize multiple major morphometric and physiological characteristics in chickens, particularly laying hens (Gallus gallus) and mallards (Anas platyrhynchos) in a meta-analysis of published data. Where such data did not exist, data are substituted from domesticated ducks (Anas platyrhynchos) and, in their absence, from chickens. The distribution of water between intracellular, extracellular, and plasma is similar in laying hens and mallards. Similarly, the lengths of the components of the small intestine (duodenum, jejunum, and ileum) are similar in chickens and mallards. Moreover, not only are the gastrointestinal absorptive areas similar in mallard and chickens but also they are similar to those in mammals when expressed on a log basis and compared to log body weight. In contrast, the following are much lower in laying hens than mallards: cardiac output (CO), hematocrit (Hct), and blood hemoglobin. There are shifts in ovary weight (increased), oviduct weight (increased), and plasma/serum concentrations of vitellogenin and triglyceride between laying hens and sexually immature females. In contrast, reproductive state does not affect the relative weights of the liver, kidneys, spleen, and gizzard.

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Comparative plasma lipid response of pullets and laying hens to estradiol and progesterone

Cited by 10 publications

References 20 publications

Dynamics of organochlorine compounds in herring gulls (Larus argentatus): II. A two‐compartment model and data for ten compounds

Dynamics of organochlorine compounds in herring gulls (Larus argentatus): II. A two‐compartment model and data for ten compounds

Regulation of plasma oestrogen by dietary fats in the laying hen: Relationships with egg weight

Quantitative Morphometric, Physiological, and Metabolic Characteristics of Chickens and Mallards for Physiologically Based Kinetic Model Development

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