Comparative Phytochemical Investigation of the Composition and Content of Biologically Active Substances in Marrubium vulgare and M. alternidens

Kurbatova, N. V.; Muzychkina, Raissa A.; Мухитдинов, Н. М.

doi:10.1023/b:conc.0000011128.64886.f4

Cited by 16 publications

(10 citation statements)

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“…Other compounds determined in the herbal material of M. vulgare are various nitrogen-containing compounds such as choline and betonicine, amino acids and alkaloid stachydrine, polysaccharides, as well as minerals, in particular potassium salts [ 2 , 17 , 42 ]. The list of individual bioactive flavonoids in Table 4 .…”

Section: Phytochemical Compositionmentioning

confidence: 99%

Marrubium vulgare L.: A Phytochemical and Pharmacological Overview

et al. 2020

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Marrubium vulgare is a plant with high bioactive potential. It contains marrubiin, a labdane diterpene that is characteristic for this genus, as well as a complex mixture of phenolic compounds. According to numerous studies, M. vulgare acts as a good antioxidant agent, and due to this, it could potentially be useful in treatments of cancer, diabetes mellitus, and liver diseases. In addition, its anti-inflammatory, wound-healing, antihypertensive, hypolipidemic, and sedative potential are discussed. Apart from that, its antimicrobial activity, especially against Gram+ bacteria, fungi, herpes simplex virus, and parasites such as Toxoplasma gondii, Trichomonas vaginalis, and Plasmodium berghei-berghei was recorded. Additionally, it could be used as a chicken lice repellent, herbicide, and natural insecticide against mosquito larvae and natural molluscicide. In veterinary medicine, M. vulgare can be used as an anthelmintic against the eggs and larvae of bovine strongyles parasites, and as an antibiotic against bovine mastitis caused by resistant bacterial strains. Due to the mentioned benefits, there is a tendency for the cultivation of M. vulgare in order to ensure high-quality raw material, but more firm scientific evidence and well-designed clinical trials are necessary for the well-established use of M. vulgare herb and its preparations.

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Section: Phytochemical Compositionmentioning

confidence: 99%

Marrubium vulgare L.: A Phytochemical and Pharmacological Overview

et al. 2020

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“…The main pharmacological activities of Marrubium vulgare have been associated to marrubiin, a bitter lactone considered as the genus chemotaxonomic marker [ 14 ]. Amino acids, polysaccharides and tannins are the major constituents of buds, flowers and fruits [ 31 ], whereas high amounts of phenols and flavonoids are mainly localized in leaves [ 29 ]. Considering that phenols and related compounds may improve the proliferation of fibroblasts and the migration of cells, thus promoting the formation of new blood vessels and capillaries [ 25 , 32 ], in the present study we focus our attention on Marrubium vulgare L. leaves.…”

Section: Introductionmentioning

confidence: 99%

Marrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties

Amri¹,

Martino

Vitulo

et al. 2017

Molecules

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Several factors contribute in wound generation, e.g., accidental traumas or surgery, and in certain cases, this dermal injury may have a devastating outcome. When skin damage occurs, the human body puts in place a sophisticated choreography, which involves numerous repairing processes to restore physiological conditions. Nevertheless, natural healing mechanisms are ineffective towards chronic or non-healing wounds and thus, therapeutic strategies may represent the only beneficial alternative to counteract these tissue insults. Over the years, numerous studies showed the great potential of plants in promoting wound healing, by virtue of their high contents in antioxidant species. These compounds trigger a molecular cascade that collimate into the promotion of reparative processes. In this article, we report on the potential effect on wound healing of Marrubium vulgare L., a medicinal plant well known for several pharmaceutical activities. To this aim, the methanolic extract was prepared and subjected to a phytochemical investigation, quantifying the amount of marrubiin via NMR and drawing the phytochemical fingerprint via high performance liquid chromatography—ultra violet/photodiode-array detection-electrospray/mass (HPLC-UV/PAD-ESI/MS) analysis. Lastly, the antioxidant properties and wound healing potential have been evaluated.

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“…Phytochemical studies performed with this species have revealed the presence of a variety of compounds, such as alkaloids, steroids, lactones, terpenes, tannins, sugars and vitamin C. Some of the compounds isolated from M. vulgare, in addition to marrubiin A study with M. vulgare and M. alternidens in various stages of development showed a similar profile of chemical constituents in both species, suggesting the presence of tannins, flavonoids, phenols, alkaloids, coumarins and saponins [8].…”

Section: Marrubium Vulgare Lmentioning

confidence: 86%

A Review of the Chemical and Pharmacological Aspects of the Genus Marrubium

Meyre‐Silva¹,

Cechinel‐Filho

2010

CPD

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The genus Marrubium (Lamiaceae) is comprised of about forty species, distributed in Europe, Asia and Brazil. Some species are traditionally used to treat various diseases, including asthma, pulmonary infections, inflammation and hypotension, as cholagogues and sedative agents, and for pain relief. A literature review on the chemical and biological aspects of these plants indicates antimicrobial activity against gram positive bacteria, analgesic properties, and anti-hypertensive, antidiabetic, antioxidant properties, among others, particularly related to the presence of diterpenes, sterols, phenylpropanoids and flavonoids. This review shows the main chemical and pharmacological aspects of the genus Marrubium, with emphasis on M. vulgare, which grows in Brazil and has been studied by us and other authors.

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Comparative Phytochemical Investigation of the Composition and Content of Biologically Active Substances in Marrubium vulgare and M. alternidens

Cited by 16 publications

References 0 publications

Marrubium vulgare L.: A Phytochemical and Pharmacological Overview

Marrubium vulgare L.: A Phytochemical and Pharmacological Overview

Marrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties

A Review of the Chemical and Pharmacological Aspects of the Genus Marrubium

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