Comparative phytochemical, cytotoxicity, antioxidant and haemostatic studies of Taraxacum officinale root preparations

Jędrejek, Dariusz; Lis, Bernadetta; Rolnik, Agata; Stochmal, Anna; Olas, Beata

doi:10.1016/j.fct.2019.02.017

Cited by 48 publications

(31 citation statements)

References 51 publications

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“…TO is also frequently used in different food products, and dietary supplements [17]. These plants were found to be rich in polyphenolic compounds, vitamins, inositol, lecithin, and minerals, and to exhibit antioxidant, anti-inflammatory, antiallergic, anti-hyperglycemic, hypolipidemic, and anticoagulant activities [9,18,19], to protect against hepatic injuries, but the mechanisms of action are still incompletely investigated [20].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Taraxacum officinale L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure

et al. 2021

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Background: Taraxacum officinale (TO) or dandelion has been frequently used to prevent or treat different liver diseases because of its rich composition in phytochemicals with demonstrated effect against hepatic injuries. This study aimed to investigate the possible preventing effect of ethanolic TO root extract (TOERE) on a rat experimental acute on chronic liver failure (ACLF) model. Methods: Chronic liver failure (CLF) was induced by human serum albumin, and ACLF was induced in CLF by D-galactosamine and lipopolysaccharide (D-Gal-LPS). Five groups (n = 5) of male Wistar rats (200–250 g) were used: ACLF, ACLF-silymarin (200 mg/kg b.w./day), three ACLF-TO administered in three doses (200 mg, 100 mg, 50 mg/kg b.w./day). Results: The in vivo results showed that treatment with TOERE administered in three chosen doses before ACLF induction reduced serum liver injury markers (AST, ALT, ALP, GGT, total bilirubin), renal tests (creatinine, urea), and oxidative stress tests (TOS, OSI, MDA, NO, 3NT). Histopathologically, TOERE diminished the level of liver tissue injury and 3NT immunoexpression. Conclusions: This paper indicated oxidative stress reduction as possible mechanisms for the hepatoprotective effect of TOERE in ACLF and provided evidence for the preventive treatment.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Taraxacum officinale L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure

et al. 2021

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“…In recent years, numerous reports have documented the contents of flavonoids or phenolic compounds in dandelion and their characterization and biological activities, and there was an association between the chemical composition and bioactivity of dandelion [5,[15][16][17][18]. However, the effects of SSF on the content, composition and antioxidant activity of flavonoids from dandelion have not been studied.…”

Section: Introductionmentioning

confidence: 99%

The effects of solid-state fermentation on the content, composition and in vitro antioxidant activity of flavonoids from dandelion

et al. 2020

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Dandelion (Taraxacum officinale), a common plant worldwide, is used as both a medicine and food. Fermentation is a food processing technology that has many advantages, such as low energy cost, changes in product characteristics, and enhanced product quality. The purpose of this study was to investigate the effect of solid-state fermentation (SSF) on the content, composition and antioxidant activity of dandelion flavonoids. Response surface methodology was used to optimize dandelion fermentation conditions. Under optimized conditions, the maximum flavone concentration was 66.05 ± 1.89 mg/g. The flavonoid content of the crude extract from fermented dandelion (FDF) was 183.72 ± 2.24 mg/g. The flavonoid compounds in the crude extracts were further identified by UPLC-ESI-MS/MS. A total of 229 flavonoid compounds were identified, and 57 differential flavonoids (including 27 upregulated and 30 downregulated flavonoids) between FDF and the crude extract of unfermented dandelion (DF) were observed, of which 25 were annotated to metabolic pathways. FDF displayed superior antioxidant activity to that of DF in in vitro DPPH radical-scavenging and reducing power assays. The favorable results of our investigation could provide a new way for the exploitation and utilization of dandelion, which could be promising for its application as an antioxidant and functional food additive with flavonoids as ingredients.

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“…Two studies found that polysaccharides from this plant have antioxidant activity in vitro (Guo et al 2019;Park Di Napoli andZucchetti Bull Natl Res Cent (2021) 45:110 et al 2014). Other studies demonstrated that polyphenols contained in Taraxacum officinale exert antioxidant effects in vitro (Aabideen et al 2020;García-Carrasco et al 2015;Hu and Kitts, 2005;Jedrejek et al 2017;Jedrejek et al 2019;Lis et al 2020) (Table 1).…”

Section: Antioxidant Activitymentioning

confidence: 96%

A comprehensive review of the benefits of Taraxacum officinale on human health

Napoli¹,

Zucchetti²

2021

Bull Natl Res Cent

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Background Taraxacum officinale (G.H. Weber ex Wiggers), commonly known as dandelion, is a herbaceous plant native to North America, Europe and Asia. This plant has been used for health purposes since ancient times. The phytochemicals present in different parts of the plant are responsible for its medicinal properties. In this review, we describe the main health properties of Taraxacum officinale. Main body of the abstract We searched for the main medicinal properties of Taraxacum officinale in the scientific literature, using the PubMed database. We selected 54 studies and we described twelve therapeutic properties, which are reported in previous studies. These properties are diuretic, hepatoprotective, anticolitis, immunoprotective, antiviral, antifungal, antibacterial, antiarthritic, antidiabetic, antiobesity, antioxidant and anticancer effects. We also found that the most frequently reported therapeutic effects include hepatoprotective, antioxidant and anticancer activities. Short conclusion In this review, we describe the medicinal properties of Taraxacum officinale reported in previous studies. Antioxidant, hepatoprotective and anticancer effects are mostly found in the scientific literature.

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Comparative phytochemical, cytotoxicity, antioxidant and haemostatic studies of Taraxacum officinale root preparations

Cited by 48 publications

References 51 publications

Protective Effects of Taraxacum officinale L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure

Protective Effects of Taraxacum officinale L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure

The effects of solid-state fermentation on the content, composition and in vitro antioxidant activity of flavonoids from dandelion

A comprehensive review of the benefits of Taraxacum officinale on human health

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