Comparative Physicochemical Evaluation of Starch Extracted from Pearl millet seeds grown in Sudan as a Pharmaceutical Excipient against Maize and Potato Starch, using Paracetamol as a model drug

Osman, Zuheir; Farah, Y.; Hassan, Hanaa A.; El-Sayed, Samiha

doi:10.1016/j.pharma.2020.08.004

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…It was also shown that while the addition of plasticizers, in this case PEG 6000, can improve the flexibility of coating materials, it potentially compromises their enteric properties. The current studies were conducted using a highly soluble and commonly used model drug, paracetamol [ 29 , 31 ]. However, further investigations involving macromolecules, such as insulin, are required to fully understand how drug-specific properties contribute to the coating integrity and drug protection of EFL, the most suitable enteric coating for SUFs among all the materials evaluated in this study [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

“…For this purpose, we prepared different mixtures comprising enteric polymers and an intermediate-molecular-weight solid-state plasticizer, polyethylenglycol (PEG) 6000, and evaluated the mechanical properties of the top coatings after spray coating. Additionally, the prepared mixtures were spray-coated on SUFs loaded with a spray-dried powder of a commonly used model drug, paracetamol [ 29 , 30 , 31 ]. The top coating was inspected before and after fitting the SUF into a capsule.…”

Section: Introductionmentioning

confidence: 99%

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Flexible Coatings Facilitate pH-Targeted Drug Release via Self-Unfolding Foils: Applications for Oral Drug Delivery

Milián-Guimerá,

De Vittorio,

McCabe

et al. 2024

Pharmaceutics

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Ingestible self-configurable proximity-enabling devices have been developed as a non-invasive platform to improve the bioavailability of drug compounds via swellable or self-unfolding devices. Self-unfolding foils support unidirectional drug release in close proximity to the intestinal epithelium, the main drug absorption site following oral administration. The foils are loaded with a solid-state formulation containing the active pharmaceutical ingredient and then coated and rolled into enteric capsules. The coated lid must remain intact to ensure drug protection in the rolled state until targeted release in the small intestine after capsule disintegration. Despite promising results in previous studies, the deposition of an enteric top coating that remains intact after rolling is still challenging. In this study, we compare different mixtures of enteric polymers and a plasticizer, PEG 6000, as potential coating materials. We evaluate mechanical properties as well as drug protection and targeted release in gastric and intestinal media, respectively. Commercially available Eudragit® FL30D-55 appears to be the most suitable material due to its high strain at failure and integrity after capsule fitting. In vitro studies of coated foils in gastric and intestinal media confirm successful pH-triggered drug release. This indicates the potential advantage of the selected material in the development of self-unfolding foils for oral drug delivery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Flexible Coatings Facilitate pH-Targeted Drug Release via Self-Unfolding Foils: Applications for Oral Drug Delivery

Milián-Guimerá,

De Vittorio,

McCabe

et al. 2024

Pharmaceutics

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“…The donor for artesunate permeation studies was either a 0.75 µg/ml artesunate solution or a 20 µg/mg powder mixture of artesunate and corn-starch. Corn-starch is an inert excipient that was used to dilute the artesunate content in the powder formulation, increase the weight of the formulation, and thus allow its reproducible weighing for the permeation study [ 35 , 36 ]. The donor solution for NaF permeation tests was prepared by dissolving NaF into KRB (25 µg/ml).…”

Section: Introductionmentioning

confidence: 99%

Pre-referral intranasal artesunate powder for cerebral malaria: a proof-of-concept study

Kouakou

Millet

Fromentin

et al. 2022

Malar J

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Background Malaria still kills young children in rural endemic areas because early treatment is not available. Thus, the World Health Organization recommends the administration of artesunate suppositories as pre-referral treatment before transportation to the hospital in case of severe symptoms with an unavailable parenteral and oral treatment. However, negative cultural perception of the rectal route, and limited access to artesunate suppositories, could limit the use of artesunate suppositories. There is, therefore, a need for an alternative route for malaria pre-referral treatment. The aim of this study was to assess the potential of intranasal route for malaria pre-referral treatment. Methods The permeability of artesunate through human nasal mucosa was tested in vitro. The Transepithelial Electrical Resistance (TEER) of the nasal mucosa was followed during the permeation tests. Beside, regional deposition of artesunate powder was assessed with an unidose drug delivery device in each nostril of a nasal cast. Artesunate quantification was performed using Liquid Chromatography coupled to tandem Mass Spectrometry. Results The experimental model of human nasal mucosa was successfully implemented. Using this model, artesunate powder showed a much better passage rate through human nasal mucosa than solution (26.8 ± 6.6% versus 2.1 ± 0.3%). More than half (62.3%) of the artesunate dose sprayed in the nostrils of the nasal cast was recovered in the olfactory areas (44.7 ± 8.6%) and turbinates (17.6 ± 3.3%) allowing nose-to-brain and systemic drug diffusion, respectively. Conclusion Artesunate powder showed a good permeation efficiency on human nasal mucosa. Moreover it can be efficiently sprayed in the nostrils using unidose device to reach the olfactory area leading to a fast nose-to-brain delivery as well as a systemic effect. Taken together, those results are part of the proof-of-concept for the use of intranasal artesunate as a malaria pre-referral treatment.

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Emerging Technologies in Millet Processing

Mazumdar

Durgalla

Akhila

2022

Handbook of Millets - Processing, Quality, and Nutrition Status

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Comparative Physicochemical Evaluation of Starch Extracted from Pearl millet seeds grown in Sudan as a Pharmaceutical Excipient against Maize and Potato Starch, using Paracetamol as a model drug

Cited by 5 publications

References 2 publications

Flexible Coatings Facilitate pH-Targeted Drug Release via Self-Unfolding Foils: Applications for Oral Drug Delivery

Flexible Coatings Facilitate pH-Targeted Drug Release via Self-Unfolding Foils: Applications for Oral Drug Delivery

Pre-referral intranasal artesunate powder for cerebral malaria: a proof-of-concept study

Emerging Technologies in Millet Processing

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