Comparative Physicochemical Analysis of Kushta-E-Murdarsang Prepared by Classical and Muffle Furness Method

Ali, Mohd Akhtar; Hamiduddin,; Zaigham, Mohammad; Nafees, S. Sheema; Jahangeer, Gazi; Ansari, Shabnam; Siddiqui, Mohammad Akhtar; Malhotra, Sharad; Maaz, Mohammad; Naquibuddin, Md.; Ikram, M.; Rather, Gazi Jahangeer

doi:10.5530/jyp.2021.13.43

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…Both KGC and KGF were evaluated for physicochemical tests like bulk density, tapped density, Hausner's ratio, Carr's index, pH, loss on drying, total ash, acid insoluble ash, water insoluble ash, water soluble ash and extractive values. 6 X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDAX), Fourier-transform infrared spectroscopy (FTIR), spectroscopic analysis and particle size and zeta potential determination have been carried out at central instrumentation facility, Jamia Millia Islamia, New Delhi.…”

Section: Modern Methodsmentioning

confidence: 99%

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Temperature Standardization and Quality Standard of Kushta e Gaodanti by Adopting Classical and Modern Methods

Fahamiya¹,

Ansari²,

ZA³

et al. 2022

JYP

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Background: Kushta Gaodanti (KG) is an essential Unani dosage form prepared by calcination according to classical texts. Standardization is paramount important to check purity and genuineness of the product. However, there are some drawbacks in the calcination process and assessing quality of the drug as per classical method. Hence, this study was aimed to evaluate the quality of KG by classical and modern methods and to develop a quality standard for KG. Methods: A multidisciplinary approach utilizing modern analytical techniques with classical tests was used. Thermogram developed when preparing KG by classical method was used to prepare the drug by Furnace method. The quality of both samples was evaluated on classical parameters like finger test, fineness test, floating test, grain test and wall test and modern physicochemical parameters like bulk density, tapped density, Hausner's ratio, Carr's index, pH, Loss on drying, ash values, and extractive values. Characterization using X-ray diffraction, Scanning Electron Microscopy, Energy Dispersive X-ray Analysis, Fourier-Transform Infrared spectroscopy, absorption spectroscopy, Zeta size and potential analysis, and heavy metal analysis have also been carried out to establish the quality standard of KG with modern analytical techniques. Results: The results of the tests done for both the preparations are comparable within experimental error when comparing with each other but non-significant differences were observed in certain parameters. Conclusion: The physicochemical and analytical parameters evaluated in this study may be considered as standard reference for KG. Furthermore, the thermogram developed in this study can be utilized to prepare the Kushta Gaodanti by the furnace method.

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Section: Modern Methodsmentioning

confidence: 99%

“…The following methods mentioned in the Unani classical texts have been used to test the quality of KGC and KGF such as loss of metallic luster, fineness test, floating test, grain test, smoke test, and wall test. [4][5][6]…”

Section: Classical Testsmentioning

confidence: 99%

Temperature Standardization and Quality Standard of Kushta e Gaodanti by Adopting Classical and Modern Methods

Fahamiya¹,

Ansari²,

ZA³

et al. 2022

JYP

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“…6 The ICP-MS method was used to compare heavy metal residues in vegetable and oil samples. 7 Unani formulation was also analysed by using ICP-MS. 8 Heavy metals in river water reference material, natural water and soil were analysed using the ICP-MS technique. [9][10][11] ICP-MS gives extensive details of the heavy metal's compounds than the conventional official methods prescribed in Pharmacopoeia's.…”

Section: Introductionmentioning

confidence: 99%

Analysis of ICH-Q3D Endorsed Elemental Impurities in Macrolide Antibiotics by ICP-MS

Mathesan,

Sekar,

Raju

et al. 2023

Ind. J. Pharm. Edu. Res

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Aim:The objective of this study was to determine the amount of twenty-three elemental impurities in Azithromycin API. A rapid, selective, precise, accurate and sensitive approach for detecting elemental impurities in Azithromycin API was developed and validated using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). Background: Conventional analytical methods used in pharmacopoeia's are less sensitive and accurate to detect heavy metal impurities. Concerning this issue, a new inductively coupled plasma mass spectrometry-based method was developed and validated as a different choice to investigate the Elemental impurities in an Azithromycin API sample. Materials and Methods: In the present research work, test samples were prepared with microwave supported acid digestion. Results: After a sequence of trails, the mixture of nitric acid, hydrochloric acid, and hydrogen peroxide (4 mL: 1 mL: 0.5 mL) with the accepted recovery range was chosen for the Azithromycin API's digestion. Conclusion: According to ICH and USP 233 guidelines, the proposed technique was successfully validated using ICP-MS for linearity, precision, accuracy, LOD, LOQ, and ruggedness.

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Comparative Physicochemical Analysis of Kushta-E-Murdarsang Prepared by Classical and Muffle Furness Method

Cited by 2 publications

References 3 publications

Temperature Standardization and Quality Standard of Kushta e Gaodanti by Adopting Classical and Modern Methods

Temperature Standardization and Quality Standard of Kushta e Gaodanti by Adopting Classical and Modern Methods

Analysis of ICH-Q3D Endorsed Elemental Impurities in Macrolide Antibiotics by ICP-MS

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